CD11b是巨噬细胞表面的一种整合素,常用于标记巨噬细胞的存在和活性,可以通过单抗偶联荧光染料的方法进行染色,比如使用CD11b-PE或CD11b-APC等抗体。MHC II分子则是抗原呈递的关键分子,其表达变化可以反映细胞的免疫状态。通过免疫荧光染色,可以直观地观察到这些标志物的表达水平和分布情况,进而分析ASM细胞在免疫应答中的...
7. 小鼠肠道组织 肠道组织里,很多老师都会研究DC细胞,但是DC细胞的标志物CD11C,MHCII在肠道巨噬细胞中也会有表达,老师们在检测和数据分析圈门时要注意哦。 8. 小鼠皮肤组织 除了CD11B,F4/80marker外,可添加EPCAM,CD64,CD24等标...
此外,通过调节TAM中的CD11b信号传导,GB1275能够增加干扰素相关因子(IFNα1、IFNβ、CXCL9和CXCL10)和抗原呈递/共刺激复合物(MHC-I、MHC-II、CD80和CD86)的表达水平,同时降低免疫抑制基因(IL10、TGFβ和精氨酸酶-1)的表达,因此,GB1275对CD11b的变构调节导致TAM极化向促炎和抗原呈递表型的转变,增强干扰素反应并...
The results also show that this vagotomy results in a trend toward a significant reduction in MHCII+/CD11+ B cells in the spleen. Conclusions Our conclusions based upon these results show that there is a direct influence of left vagus nerve innervation on the number of splenic B cells and ...
与Ly6GhighG-MDSC亚群相比,在所有66个使用的标记物中,只有CXCR4、F4/80、MHC II和CD205在Ly6GlowG-MDSC中高表达(图4C)。此外,对Ly6Glow和Ly6Ghigh的G-MDSC亚群进行分类,通过质谱检测蛋白表达差异(图4D1)。研究发现,与Ly6GlowG-MD...
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism Authors - Ling Huang View Article mouse FC Cell Commun Signal Transfer of cGAMP from neuron to microglia activates microglial type I interferon responses after subarachnoid hemorrhage Authors - ...
结果:用 ADH-503 (GB1275)处理后,巨噬细胞的 MHCI、MHCII、CD80 和 CD86 表达水平更高,表明剩余巨噬细胞的抗原呈递特性有所改善。[1] 体内活性 方法:在大鼠和 C57/B6 小鼠中,给予ADH-503 (GB1275) (30,100mg / kg,口服)测试药代动力学 (PK) 和安全性。
Control of the intracellular protozoan, Leishmania major, requires major histocompatibility complex class II (MHC II)-dependent antigen presentation and CD4+ T cell T helper cell 1 (Th1) differentiation. MHC II-positive macrophages are a primary target of infection and a crucial effector cell control...
MHC Class II is heterogeneously expressed on lung monocytes but not residential AM^s in different inflammatory lung conditions, emphasizing the selectivity of CD11b as a heterogeneously expressed marker of residential AM^s (see Supplementary Figure S2e online). A second subset of CD11cnegCD11bpos ...
Conventional APCs that express MHC class II (MHCII) and co‐stimulatory molecules include dendritic cells (DCs) and macrophages. Beyond these conventional APCs, immune stimulatory cells have been more recently shown to extend to a class of atypical APCs, composed of mast cells, basophils, and eos...