CD11c+ MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor immunity against a mouse fibrosarcomaCancer, Immunotherapy, Neoepitopes, Vaccine, Dendritic cells, Adjuvant...
尽管免疫功能会随着胃肠道的长度而变化,但尚不清楚不同区域、不同免疫细胞或其他来源的EV在应对肠道屏障挑战方面是否具有不同的作用。众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的...
结果 癌组织中CD11c和MVD明显高于癌旁组织(P<0.01);癌组织中MHC-Ⅱ明显低于癌旁组织(P<0.01).MVD与MHC-Ⅱ呈负相关性(r =-0.480,P<0.01),而与CD11c则无明显相关性.癌组织中各项指标的表达与肝癌的转移、TNM分期存在相关性(P<0.05).结论 肝癌组织中CD11c、MHC-Ⅱ的表达与肝癌的转移及TNM分期密切相关;MVD的...
CD11c(+) MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor ... H Ebrahimi-Nik,WL Corwin,Shcheglova, TatianaDas Mohapatra, AlokMandoiu, Ion I.Srivastava, Pramod K. - 《Cancer Immunology Immunotherapy》 被...
众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的耐受性。此外,从小鼠IECs顶端和基底外侧表面释放的外泌体在蛋白质组成上有所不同,表明EVs的特殊功能基于起源细胞或释放机制。然而,胃肠道内不同免疫细胞类型产生的EV的特性、内容和功能尚不明确。
As such, macrophages cannot be accurately distinguished from cDCs in either human or mouse tumors using only the common markers CD11c, CD11b, and MHCII. This has resulted in confusion in the field as properties of macrophages are ascribed to tumor cDCs. IRF8-dependent cDCs can be identified ...
Additionally, the large amount of fOVA delivered with α-DC-ZZ-BNC-fOVA was translocated into cytosol compartment in DCs (Fig. 1c), suggesting that the Ag translocation could facilitate cellular immunity depending on MHC class I (i.e., cross-presentation). Membrane fusogenic activity from...
MHC Class II Antibody, anti-mouse 16,00 EUR View product CD11c Antibody, anti-mouse 43,00 EUR View product MiniMACS™ Separator and Starting Kit 276,00 EUR View product MS Columns 209,00 EUR View product 130-095-927Lung Dissociation Kit, mouse 621,00 EUR Add to cart Specifications...
Although CD11c(med) cells are associated with the initiation of vascular expansion, CD11c(hi)MHC class II (MHC II)(med) dendritic cells (DCs) accumulate later, and their short-term depletion in mice abrogates the re-establishment of vascular quiescence and stabilization. CD11c(hi)MHC II(med) ...
The magnitude and quality of T cell responses generated when Ag is targeted to receptors on DC is influenced by both the specific receptor targeted and its distribution among DC subsets. Here we examine the targeting of the model Ag OVA to potential DC targets, including CD11c, CD205, MHC cl...