CD11c+ MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor immunity against a mouse fibrosarcomaCancer, Immunotherapy, Neoepitopes, Vaccine, Dendritic cells, Adjuvant...
CD11c(+) MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor ... H Ebrahimi-Nik,WL Corwin,Shcheglova, TatianaDas Mohapatra, AlokMandoiu, Ion I.Srivastava, Pramod K. - 《Cancer Immunology Immunotherapy》 被...
They do not express pan markers of myeloid DCs (CD11c), plasmacytoid DCs (Ly6C), or macrophages (F4/80), and their frequency is inversely correlated with myeloid‐derived suppressor cells (MDSCs) in tumor‐bearing mice. Among splenocytes, they are more abundant than DCs and macrophages, ...
Clinically Relevant Allergen Mixture Induces Robust Immune Response By Increasing CD11c+CD11b+MHCIIhiCD103int Lung Dendritic CellsFemale Balb/c mice were sensitized intranasally and challenged by aerosolizing a combination of house dust mite, ragweed and or PBS for a total of 5 weeks. Lung tissue...
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Fig. 1: Type II alveolar cells (AT2s) constitutively express MHCII independent of conventional inflammatory signals. a–cMHCII protein expression by AT2s from naive C57Bl/6 (B6) wild-type (WT) and MHCII−/−mice (a) and AT2s, CD103+dendritic cells (CD103+DC), B cells, alveolar...
B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC), perhaps by increased acquisition of antigen for presentation to follicular helper T cells and improved T-cell help. In this model for affinity-dependent selection
Among these, the CD11c(+) MHCIIlo sub-set, distinguishable by a distinct transcriptional profile including a higher expression of heat shock protein receptors CD91 and LOX1, mannose receptors and TLRs, is significantly superior to the CD11c(+) MHCIIhi sub-set. Finally, dendritic cells exert ...
Among these, the CD11c+ MHCIIlo sub-set, distinguishable by a distinct transcriptional profile including a higher expression of heat shock protein receptors CD91 and LOX1, mannose receptors and TLRs, is significantly superior to the CD11c+ MHCIIhi sub-set. Finally, dendritic cells exert their ...
They do not express pan markers of myeloid DCs (CD11c), plasmacytoid DCs (Ly6C), or macrophages (F4/80), and their frequency is inversely correlated with myeloid‐derived suppressor cells (MDSCs) in tumor‐bearing mice. Among splenocytes, they are more abundant than DCs and macrophages, ...