CD11c+ MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor immunity against a mouse fibrosarcomaCancer, Immunotherapy, Neoepitopes, Vaccine, Dendritic cells, Adjuvant...
尽管免疫功能会随着胃肠道的长度而变化,但尚不清楚不同区域、不同免疫细胞或其他来源的EV在应对肠道屏障挑战方面是否具有不同的作用。众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的...
7. 小鼠肠道组织 肠道组织里,很多老师都会研究DC细胞,但是DC细胞的标志物CD11C,MHCII在肠道巨噬细胞中也会有表达,老师们在检测和数据分析圈门时要注意哦。 8. 小鼠皮肤组织 除了CD11B,F4/80marker外,可添加EPCAM,CD64,CD24等标...
In these mice, colitis is associated with expansion of T helper type 1 (Th1) and Th17 cell populations and a decrease in the number of FoxP3 + regulatory T (Treg) cells, and the pathology is linked to the inability of intestinal Cnb1-deficient CD11c high MHCII + cells to express IL-...
[3]. Similarly, both populations of cDCs express CD11b, albeit to varying degrees. As such, macrophages cannot be accurately distinguished from cDCs in either human or mouse tumors using only the common markers CD11c, CD11b, and MHCII. This has resulted in confusion in the field as ...
Clinically Relevant Allergen Mixture Induces Robust Immune Response By Increasing CD11c+CD11b+MHCIIhiCD103int Lung Dendritic CellsClinically Relevant Allergen Mixture Induces Robust Immune Response By Increasing CD11c+CD11b+MHCIIhiCD103int Lung Dendritic CellsFemale Balb/c mice were sensitized intranasall...
(d) Intracellular IRF4 staining or GFP expression from bone marrow pre-DCs (Lin− CD11clo/+ CD11b− MHCIIlo/− Flt3+) and DCs (CD11c+ MHCII+) and lung lymphocytes and DCs (CD11c+ MHCII+ Autolo) from naïve Irf4fl/fl and Irf4fl/flCD11cCre. (e) HDM-challenged lung DC ...
众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的耐受性。此外,从小鼠IECs顶端和基底外侧表面释放的外泌体在蛋白质组成上有所不同,表明EVs的特殊功能基于起源细胞或释放机制。然而,胃肠道内不同免疫细胞类型产生的EV的特性、内容和功能尚不明确。
Among these, the CD11c(+) MHCIIlo sub-set, distinguishable by a distinct transcriptional profile including a higher expression of heat shock protein receptors CD91 and LOX1, mannose receptors and TLRs, is significantly superior to the CD11c(+) MHCIIhi sub-set. Finally, dendritic cells exert ...
CD11c+MHCIIloGM-CSF-BMDCs mediate the most potent neoepitope-elicited tumor protection GM-CSF-BMDCs were sorted based on expression of CD11c and MHC class II into three sub-populations similar to the sorting strategy adopted earlier [33] (Fig.3a): undifferentiated cells without CD11c and MHCII ...