CD11c+ MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor immunity against a mouse fibrosarcomaCancer, Immunotherapy, Neoepitopes, Vaccine, Dendritic cells, Adjuvant...
尽管免疫功能会随着胃肠道的长度而变化,但尚不清楚不同区域、不同免疫细胞或其他来源的EV在应对肠道屏障挑战方面是否具有不同的作用。众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的...
尽管免疫功能会随着胃肠道的长度而变化,但尚不清楚不同区域、不同免疫细胞或其他来源的EV在应对肠道屏障挑战方面是否具有不同的作用。众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的耐受性。此外,从小鼠IECs顶端和基底外侧表面释放的外泌体在蛋白质组成上有所...
CD11c(+) MHCIIlo GM-CSF-bone marrow-derived dendritic cells act as antigen donor cells and as antigen presenting cells in neoepitope-elicited tumor ... H Ebrahimi-Nik,WL Corwin,Shcheglova, TatianaDas Mohapatra, AlokMandoiu, Ion I.Srivastava, Pramod K. - 《Cancer Immunology Immunotherapy》 被...
As such, macrophages cannot be accurately distinguished from cDCs in either human or mouse tumors using only the common markers CD11c, CD11b, and MHCII. This has resulted in confusion in the field as properties of macrophages are ascribed to tumor cDCs. IRF8-dependent cDCs can be identified ...
脉络从巨噬细胞(CD11b+CD45hiCD163-MHCIIhi) 6. 小鼠脾脏组织 巨噬细胞也一般用CD11blow、F4/80+作为检测标志物,也可用CD11blow、CD64+作为检测标志物,还特征性表达MerTK,CD68。脾脏里的巨噬细胞细分的话,还可以分为红髓和...
Expression of IL-23 by monocytes was acquired during their differentiation in the intestine and correlated with the expression of major histocompatibility complex class II (MHCII) and CD64. In contrast,Batf3-dependent CD103+CD11b-dendritic cells were dispensable for bacteria-induced colitis in this...
Clinically Relevant Allergen Mixture Induces Robust Immune Response By Increasing CD11c+CD11b+MHCIIhiCD103int Lung Dendritic CellsClinically Relevant Allergen Mixture Induces Robust Immune Response By Increasing CD11c+CD11b+MHCIIhiCD103int Lung Dendritic CellsFemale Balb/c mice were sensitized intranasally...
Among these, the CD11c(+) MHCIIlo sub-set, distinguishable by a distinct transcriptional profile including a higher expression of heat shock protein receptors CD91 and LOX1, mannose receptors and TLRs, is significantly superior to the CD11c(+) MHCIIhi sub-set. Finally, dendritic cells exert ...
众所周知,IEC衍生的囊泡,称为“toleroomes”,显示具有结合抗原的MHCII,并能到达淋巴结,诱导对口服抗原的耐受性。此外,从小鼠IECs顶端和基底外侧表面释放的外泌体在蛋白质组成上有所不同,表明EVs的特殊功能基于起源细胞或释放机制。然而,胃肠道内不同免疫细胞类型产生的EV的特性、内容和功能尚不明确。