1. An oral Cbl-b inhibitor with sustained T cell activation demonstrated robust anti-tumor efficacy along with enhanced infiltration and activation of functional T cells.2024 AACR. 2. GSC000190, a highly potent inhibitor...
DescriptionCbl-b-IN-1 is a potent Cbl-b inhibitor (IC50 <100 nM) with potential anticancer activity for the study of intestinal inflammation. Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. ...
针对Cbl-b靶点设计的抑制剂小分子一般结合在非活性构象的TKB结构域和LHR结构域之间，将蛋白稳定在非活性封闭构象，类似于SHP2变构抑制剂的机理。Kimani S, Perveen S, Szewczyk M, et al. Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor[J]. bioRxiv, 2023: 2023.05. 05.539612...
where it negatively regulates the activity of immune cells. Cbl-b has specifically been identified as an attractive target for cancer immunotherapy due to its role in promoting an immunosuppressive tumor environment. A Cbl-b inhibitor, Nx-1607, is currently in phase I clinical trials for ...
Cbl-b inhibitor selected from inhibitor nucleic acids, which reduce or inhibit Cbl-b expression, in combination with at least one cytokine or an interferon selected from * IL-2 and one or more additional cytokines or interferons selected from IL- 12, IL-23, IFN-alpha and IFN-beta, or * ...
Cbl-b-IN-1 (example 519) is a Cbl-b inhibitor, extracted from patent WO2019148005A1, with an IC50 <100 nM[1]. [1]. BARSANTI PAUL A (US), et al. INHIBITORS OF CBL-B AND METHODS OF USE THEREOF. WO/2019/148005A1. 没有评价数据 C11 BODIPY 581/591 ￥350.00 ￥1625.00 Angeli’...
Kimani S, Perveen S, Szewczyk M, et al. Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor[J]. bioRxiv, 2023: 2023.05. 05.539612. Cbl-b可负向调节TCR(T细胞受体)、BCR(B细胞受体)和FCER1(高亲和力免疫球蛋白ε受体)信号转导途径;同时,在受体酪氨酸激酶(RTKs)的内吞和溶酶...
Description Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1]. Related Catalog Research Areas >> Cancer ...
In Vitro: Cbl-b-IN-2 (Example 8) is a Cbl-b inhibitor with IC50 values range of 5.1-100 nM and 1 nM in high and low concentration of Cbl-b, respectively. 相关产品:VH285-PEG4-C4-Cl | (S,R,S)-AHPC-PEG5-COOH | (S,R,S)-AHPC-PEG3-N3 | (S,R,S)-AHPC-PEG2-N3 | (S...
Kimani S, Perveen S, Szewczyk M, et al. Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor[J]. bioRxiv, 2023: 2023.05. 05.539612. Cbl-b可负向调节TCR(T细胞受体)、BCR(B细胞受体)和FCER1(高亲和力免疫球蛋白ε受体)信号转导途径;同时,在受体酪氨酸激酶(RTKs)的内吞和溶酶...