TargetMol Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/...
Cbl-b-IN-3 (Compound 23) 是 casitas B 系淋巴瘤原癌基因-b (Cbl-b) 抑制剂, IC50 为 < 1 nM。 Cbl-b 是一种 E3 泛素连接酶,负调控 T 细胞活化。 此产品仅用于科学研究,我们不为任何个人用途提供产品和服务 库存:现货 可选规格 包装
英文名称:Cbl-b-IN-3 CAS:2573775-59-2 纯度:98% HPLC 包装信息:5mg,10mg,50mg,100mg,1g,5g 广州优南科技有限公司 联系电话: 020-82000279 18988968278 产品介绍: 英文名称:Cbl-b-IN-3 CAS:2573775-59-2 纯度:98% 包装信息:5mg;10mg;50mg;100mg ...
MCE 国际站:Cbl-b-IN-3 产品活性:Cbl-b-IN-3 (Compound 23) 是 casitas B 系淋巴瘤原癌基因-b (Cbl-b) 抑制剂, IC50 为< 1 nM。 Cbl-b 是一种 E3 泛素连接酶,负调控 T 细胞活化。 研究领域:Metabolic Enzyme/Protease 作用靶点:E1/E2/E3 Enzyme In Vitro: Cbl-b-IN-3 (Compound 23) enhanc...
用途Cbl-b-IN-3 (Compound 23) 是 casitas B 系淋巴瘤原癌基因-b (Cbl-b) 抑制剂, IC50 为 < 1 nM。 Cbl-b 是一种 E3 泛素连接酶,负调控 T 细胞活化。用途Cbl-b-IN-3(化合物23)是一种casitas b系淋巴瘤原癌基因-b(Cbl-b)抑制剂,IC50<1nM。Cbl-b是一种负调节T细胞活化的E3泛素连接酶[1]...
Surprisingly, Cbl-3 overexpression dramatically stabilizes activated Ret and enhances neuronal survival, even though Cbl-family E3 ligases normally function to trigger RTK downregulation. In combination with CD2AP, however, Cbl-3 promotes Ret degradation rapidly and almost completely blocks survival pro...
Previous results identified a gene from a protein kinase, denominated ScCIPK8 (Sugarcane CBL-interacting protein kinase 8) that could participate in signal transduction pathways, that was already differentially expressed in a contrastant population with higher amount of sugar in sugarcane in microarrays...
Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation. Integrin crosslinking on human B cells induces tyrosine phosphorylation of a set of proteins ranging from 105 to 130 kDa, among which is the focal adhesion... SN Manié,M Sattler...
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