英文名称Cbl-b-IN-1 生化机理Cbl-b-IN-1(例 519)是一种 Cbl-b 抑制剂,摘自专利 WO2019148005A1,IC 50 <100 nM。 储存温度-20°C储存 运输条件超低温冰袋运输 产品介绍 Cbl-b-IN-1 (example 519) is a Cbl-b inhibitor, extracted from patent WO2019148005A1, with an IC 50 <100 nM ...
中文名:CBL-B-IN-1,英文名:2-Pyridinecarboxamide, 4-(5-azaspiro[2.4]hept-5-ylmethyl)-6-cyclopropyl-N-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-,CAS:2368841-84-1,化学式:C29H34N6O2,分子量:498.62,MSDS.
T cell-intrinsic transforming growth factor β (TGFβ) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate the sensitivity of T cells to TGFβ; however, the mechanism underlying this process is unknown. This study...
Icotinib caused G1 phase arrest and increased the rate of apoptosis in HCC827 cells. Further study revealed that icotinib inhibited the phosphorylation of EGFR, Akt, and ERK. In addition, icotinib upregulated ubiquitin ligase Cbl-b expression. These observations suggest that icotinib-induced up...
Furthermore, ursolic acid suppressed NF-κB activation and inhibited the downregulation of Cbl-b in wild-type T cells. NF-κBp65 specifically bound to an 11-bp NF-κB consensus sequence (gcaggaagtcc) in the Cbl-b promoter. Binding of NF-κB to this sequence suppressed Cbl-b transcription,...
C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carbosy-terminus. Wilhelmsen K, Burkhalter S, van der GP 2002 C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-... Wilhelmsen,Kevin,Burk...