中文名:CBL-B-IN-1,英文名:2-Pyridinecarboxamide, 4-(5-azaspiro[2.4]hept-5-ylmethyl)-6-cyclopropyl-N-[3-[3-[(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-3-oxetanyl]phenyl]-,CAS:2368841-84-1,化学式:C29H34N6O2,分子量:498.62,MSDS.
英文名称 Cbl-b-IN-1 生化机理 Cbl-b-IN-1(例 519)是一种 Cbl-b 抑制剂,摘自专利 WO2019148005A1,IC 50 <100 nM。 储存温度 -20°C储存 运输条件 超低温冰袋运输 产品介绍 Cbl-b-IN-1 (example 519) is a Cbl-b inhibitor, extracted from patent WO2019148005A1, with an IC 50 <100 nM...
英文名称 Cbl-b-IN-1 生化机理 Cbl-b-IN-1(例 519)是一种 Cbl-b 抑制剂,摘自专利 WO2019148005A1,IC 50 <100 nM。 储存温度 -80℃储存 运输条件 超低温冰袋运输 产品介绍 Cbl-b-IN-1 (example 519) is a Cbl-b inhibitor, extracted from patent WO2019148005A1, with an IC 50 <100 nM...
Cbl-b-IN-1 (example 519) 是 Cbl-b 的抑制剂,信息来自专利 WO2019148005A1,其 IC50 值 <100 nM。 此产品仅用于科学研究,我们不为任何个人用途提供产品和服务 库存:现货 可选规格 包装 5mg 10mg 25mg 50mg 100mg 数量 确认取消 ￥4140-30780
中文名称: Cbl-b-IN-1 英文名称: Cbl-b-IN-1 CAS No.: 2368841-84-1 分子式: C29H34N6O2 分子量: 498.6193 如需查看该化合物的详细结构式,mol文件,smile,InChi 请点击:Cbl-b-IN-1结构式 下载该化合物MOL文件: Cbl-b-IN-1MOL PubChem CID: 139360969 快速询单 ...
T cell-intrinsic transforming growth factor β (TGFβ) receptor signaling plays an essential role in controlling immune responses. The RING-type E3 ligase Cbl-b has been shown to mediate the sensitivity of T cells to TGFβ; however, the mechanism underlying this process is unknown. This study...
Icotinib caused G1 phase arrest and increased the rate of apoptosis in HCC827 cells. Further study revealed that icotinib inhibited the phosphorylation of EGFR, Akt, and ERK. In addition, icotinib upregulated ubiquitin ligase Cbl-b expression. These observations suggest that icotinib-induced up...
Icotinib caused G1 phase arrest and increased the rate of apoptosis in HCC827 cells. Further study revealed that icotinib inhibited the phosphorylation of EGFR, Akt, and ERK. In addition, icotinib upregulated ubiquitin ligase Cbl-b expression. These observations suggest that icotinib-induced up...
In addition, icotinib upregulated ubiquitin ligase Cbl-b expression. These observations suggest that icotinib-induced upregulation of Cbl-b is responsible, at least in part, for the antitumor effect of icotinib via the inhibition of phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein...
Furthermore, ursolic acid suppressed NF-κB activation and inhibited the downregulation of Cbl-b in wild-type T cells. NF-κBp65 specifically bound to an 11-bp NF-κB consensus sequence (gcaggaagtcc) in the Cbl-b promoter. Binding of NF-κB to this sequence suppressed Cbl-b transcription,...