CBL-Bi's impact on potential substrates of CBL-B's E3 ligase activity was monitored for changes in treated human PBMCs using flow cytometry. Results When comparing Jurkat cells treated with anti-CD3 to those treated with anti-CD3 and CBL-Bi, significant differences were observed in tyrosine, ...
Simple Western™ 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. Protocol Specificity / Sensitivity Cbl-b (D3C12) Rabbit mAb recognizes end...
Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/- t 细胞...
英文名称: Cbl-b-IN-2 总访问: 23 国产/进口: 进口 半年访问: 6 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 1 mg; 5 mg 最后更新: 2025-2-13 货号: HY-141431 CAS 号: 2503325-21-9 参考报价: 3880; 9700 立即询价 电话咨询 ...
TargetMol Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂(ic50 < 1 nM)。Cbl-b 是一种环型E3泛素蛋白连接酶,与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85,通过其E3泛素连接酶活性,参与了p85向CD28和T 细胞抗原受体ζ的募集,抑制PI3K 抑制了Cblb-/...
分享首款 RING E3 连接酶催化抑制剂NX-1607发现过程。NX-1607通过锁定分子在非活性状态,以分子内分子胶(Intramolecular Glue)的机制抑制CBL-B的E3 连接酶活性,以增强肿瘤免疫,治疗肿瘤。 Part 1. CBL-B背景 •CBL-B是一种E3泛素连接酶,在免疫系统的细胞中高度表达。•CBL-B调节T, B和NK细胞活化。•阻断...
Fig. 1: C7683 potently stabilizes both full-length and TKBD-LHR-RING Cbl-b proteins in DSF assays. The chemical structure of C7683 is presented. C7683 stabilized (a) TKBD-LHR-RING and (b) full-length Cbl-b at 3 μM with ΔTm values of 10 ± 0.4 and 12 ± 0.2...
摩库(MolCore)专业生产高纯度CAS No.2573775-59-2, Cbl-b-IN-3 ,其分子式为null,分子量null,产品符合ISO认证体系,适用于全球制药研发及质量控制需求。 2573775-59-2 MSDS,定制合成.
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Cbl-b-IN-17 (Example-40) 是 Cbl-b 的抑制剂,其 IC50 值<100 nM。更多产品详情查看:www.medchemexpress.cn/cbl-b-in-17.html Cbl-b-IN-17 | MedChemExpress (MCE)由MedChemExpress (MCE) 为您提供,如您想了解更多关于Cbl-b-IN-17 | MedChemExpress (MCE)报价、CAS号、货号、参数等信息 ,欢迎...