参考文献: 1. An oral Cbl-b inhibitor with sustained T cell activation demonstrated robust anti-tumor efficacy along with enhanced infiltration and activation of functional T cells.2024 AACR. 2. GSC000190, a highly poten...
产品名称价格公司名称报价日期 B-Raf抑制剂(B-Raf inhibitor 1) 询价 VIP6年 上海泽叶生物科技有限公司 2025-02-08 b-AP15 (DUB抑制剂) 询价 碧云天生物技术有限公司 2025-01-30 人抑制素B(INH-B)Elisa试剂盒 ￥1200 VIP4年 上海雅吉生物科技有限公司 2025-02-08...
Cbl-b-IN-1 (example 519) is a Cbl-b inhibitor, extracted from patent WO2019148005A1, with an IC50 <100 nM[1]. [1]. BARSANTI PAUL A (US), et al. INHIBITORS OF CBL-B AND METHODS OF USE THEREOF. WO/2019/148005A1. 没有评价数据 C11 BODIPY 581/591 ￥350.00 ￥1625.00 Angeli’...
prevention or treatment of a fungal infection in a patient, a Cbl-b inhibitor comprising a binding peptide of Syk, a fusion peptide comprising a cell delivery portion and a Cbl-b binding peptide, wherein the Cbl-b binding peptide binds to the TKB domain of Cbl-b, kits and uses for the...
we determined the co-crystal structure of Cbl-b with C7683, revealing the compound’s interaction with both the TKBD and LHR, but not the RING domain. Here, we provide structural insights into a novel mechanism of Cbl-b inhibition by a small-molecule inhibitor that locks the protein in an...
针对Cbl-b靶点设计的抑制剂小分子一般结合在非活性构象的TKB结构域和LHR结构域之间，将蛋白稳定在非活性封闭构象，类似于SHP2变构抑制剂的机理。Kimani S, Perveen S, Szewczyk M, et al. Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor[J]. bioRxiv, 2023: 2023.05. 05.539612...
Names Name Cbl-b-IN-3 Cbl-b-IN-3 Biological ActivityDescription Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1]. ...
Indeed, using a dual Cbl-b/c-Cbl small molecule inhibitor, we demonstrate that Cbl blockade enhances T cell activity under standard and sub-optimal stimulation conditions. Moreover, Cbl inhibition increases mouse syngeneic tumor control alone or in combination with 伪-PD-1, as described below....
Cbl-b-IN-2 可用于调节免疫系统和易受免疫系统调节的疾病。Cbl-b-IN-2 (Example 8) 还可单独或与一种或多种免疫检查点抑制剂,抗肿瘤剂和放射剂联合应用于癌症。 研究领域:PROTAC 作用靶点:E3 Ligase Ligand-Linker Conjugates In Vitro: Cbl-b-IN-2 (Example 8) is a Cbl-b inhibitor with IC50 ...
Kimani S, Perveen S, Szewczyk M, et al. Probing the mechanism of Cbl-b inhibition by a small-molecule inhibitor[J]. bioRxiv, 2023: 2023.05. 05.539612. Cbl-b可负向调节TCR(T细胞受体)、BCR(B细胞受体)和FCER1(高亲和力免疫球蛋白ε受体)信号转导途径;同时,在受体酪氨酸激酶(RTKs)的内吞和溶酶...