1. An oral Cbl-b inhibitor with sustained T cell activation demonstrated robust anti-tumor efficacy along with enhanced infiltration and activation of functional T cells.2024 AACR. 2. GSC000190, a highly potent inhibitor...
The present invention relates to a Cbl family inhibitor for use in the prevention or treatment of various diseases in patients (wherein the Cbl family inhibitor comprises a Syk binding peptide, a cell delivery moiety, and a Cbl family TKB domain binding peptide). Where Cbl family TKB domain ...
Cbl is an adaptor protein that is phosphorylated and recruited to several receptor and non-receptor tyrosine kinases upon their activation. After binding to the activated receptor, Cbl plays a key role as a kinase inhibitor and as an E3 ubiquitin ligase, thereby contributing to receptor down-regul...
The ERK1/2 inhibitor PD98059, the PI3K/Akt inhibitor LY294002, and the c-Src inhibitor PP2 all enhanced TAM action. Moreover, the ubiquitin ligase c-Cbl was up-regulated during this process. Over-expression of c-Cbl significantly enhanced the apoptosis-inducing effects of TAM, while 70Z/...
When these mice were mated to FLT3-ligand-deficient mice or treated with the FLT3 inhibitor AC220, the mice did not develop a MPD 14, 15. This indicated that deregulated FLT3 signaling promotes disease development, and that c-Cbl E3 ligase activity maintains a level of FLT3 signaling that ...
Treatment of C2C12 cells with the lysosomal inhibitor chloroquine for 1, 3, and 6 h after the induction of terminal differentiation for 48 h showed increasing amounts of c-Cbl protein physically associated with NTM after stimulation with chloroquine (Fig. 8). This interaction strengthens the evide...
Moreover, PP2, a specific inhibitor of c-src, almost completely eliminated the phosphorylation of c-Cbl induced by tetrandrine or DIM (Fig. 6e). While, c-Cbl siRNA did not affect the enhancement of tetrandrine and DIM on the activation of c-src (Fig. 6f). These results indicated that ...
Need us to run inhibitor screens or profile your compounds against C-CBL-driven Tyro3 Ubiqutination? Check out ourUbiquitination Screening Services. ● Synonyms Tyrosine-protein kinase receptor, TYRO3, BYK, DTK, RSE, SKY, TIF, CBL2, RNF55, E3 ubiquitin-protein ligase CBL, Casitas B-lineage...
Livin、c-cbl在白血病细胞中的表达及临床意义 研究背景与目的 凋亡抑制蛋白(Inhibitor of apoptosisprotein,IAP)是一类含众多成员的凋亡抑制蛋白家族,在抑制凋亡和促进肿瘤细胞增生中起着重要的作用。Livin是新发... 陈保荣 - 广州医学院 被引量: 0发表: 2010年 ...
HER2 knockdown by siRNA in BT474 cells reduced ER-c-Src-HER2 complex formation and reversed tamoxifen resistance. ER-c-Src-HER2 complex formation was also disrupted and tamoxifen resistance was reversed in BT474 cells by the c-Src inhibitor PP2 and HER2 antibody trastuzumab. Nystatin, a lipid ...