The demonstration of protein sequence and functional homology of the Caenorhabditis elegans programmed cell death gene product, CED-3, with human caspase-1 in 1993 triggered an explosion of research activities toward the understanding of molecular mechanisms of apoptosis. During the past 15 years, a ...
CED-3, with human caspase-1 in 1993 triggered an explosion of research activities toward the understanding of molecular mechanisms of apoptosis. During the past 15 years, a plethora of knowledge has been obtained on the mammalian caspases, the homologs of CED-3,...
Since the late 20th century, researchers have known that caspases are a pillar of cell death, particularly apoptosis. However, recent advances in cell biology have unraveled the multiple roles of caspases. These enzymes have an unconventional role in cell proliferation, differentiation, and invasion. ...
Functional genetic studies revealed that both caspases are activated to a similar extent and together account for all the detected effector caspase activity in the WDs, although Dcp-1 is far less efficient in triggering apoptosis than Drice in this context (albeit both caspases cleave CPV in a s...
Caspases in apoptosis and beyond The demonstration of protein sequence and functional homology of the Caenorhabditis elegans programmed cell death gene product, CED-3, with human caspase-1... J Li,J Yuan - 《Oncogene》 被引量: 1127发表: 2008年 ...
Inflammatory and apoptotic caspases are central players in inflammation and apoptosis, respectively. However, recent studies have revealed that these caspases have functions beyond their established roles. In addition to mediating cleavage of the inflammasome-associated cytokines interleukin-1β (IL-1β) ...
Conversely, depletion of HsTSN by siRNA sufficed to promote apoptosis in human cells. Furthermore, caspase-3-dependent cleavage of HsTSN inhibited its ribonuclease activity and impaired its stimulatory function in pre-mRNA splicing.11 The aforementioned experiments nicely illustrate how caspases and ...
Mitochondrial apoptosis is mediated by BAK and BAX, two proteins that, upon activation, oligomerise in the mitochondrial outer-membrane to induce its permeabilisation (MOMP). This event allows cytochrome-c efflux from the mitochondria subsequently triggering a family of cysteine-dependent, aspartic-...
Cell death in development. CaspasesSignal TransductionApoptosisMorphogenesisCell DeathCell CyclePlantsEnzyme ActivationCell. 1999 Jan 22;96(2):245-54. Research Support, Non-U.S. Gov'... DL Vaux,SJ Korsmeyer - 《Cell》 被引量: 4530发表: 1999年 Cell Death Independent of Caspases: A Review Patt...
A long way to go: caspase inhibitors in clinical use Article Open access 15 October 2021 Apoptosis: Pathways, Molecules and Beyond Chapter © 2015 References Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326(Pt 1):1–16 Article CAS PubMed PubMed Central Google Schol...