Inflammatory caspases do not function in apoptosis and instead are involved in inflammatory cytokine signaling, danger signals and other types of cell death like pyroptosis. Thus, these caspases play a key role in innate immune response by inducing pyroptosis to stop intracellular replication of ...
So, some selenocompounds, such as SeO2 involve the activation of caspase-3 while sodium selenite induces apoptosis in the absence of the activation of caspases. Modulation of mitochondrial functions has been reported to play a key role in the regulation of apoptosis and also to be one of the...
Apoptosis, the most common process of cell death, is a highly regulated, active mechanism mediated by the caspase cascade. It can be divided into internal (also known as mitochondrial) or external apoptotic pathways, depending on the inducing stimuli. Activation of the caspase cascade ultimately le...
Protein kinase C (PKC) inhibits fas receptor-induced apoptosis through modulation of the loss of K+ and cell shrinkage. A role for PKC upstream of caspases. Cell shrinkage and loss of intracellular K(+) are early requisite features for the activation of effector caspases and apoptotic nucleases...
Chemotherapy/radiation p53 NOXA PUMA BAK BAX Bcl-2 Bcl-xL Bcl-W Mcl-1 Bcl-B Bfl-1 DNA damage ABT-737 8J 8Q Small molecule antagonists mitochondria Cyt C pro-Casp-9 Smac APAF-1 IAP apoptosome Caspases 3,6,7 APOPTOSIS Figure 1 Mechanism of Bcl-2 antagonists in cell stress response. ...
RCSC was found to be an effective anti-cancer agent on cell lines of multiple cancer types with the best effect on lung cancer cell lines. A possible mechanism for the anticancer activity of RCSC is through induction of apoptosis as observed in the lung cancer cell line, NCI-H460.Peer...
In conclusion, in ECV304 cells 7-ketocholesterol induces some typical hallmarks of necrotic cell death but not of apoptosis. 展开 关键词: 7-ketocholesterol Staurosporine Apoptosis Necrosis Caspases Cytochrome c Cell morphology Intracellular pH
Nonetheless, within a cellular machinery such as AM it is possible to identify: (i) putative core nodes, ubiquitously expressed genes endowed with a central biomolecular role in the activation or inhibition of apoptosis (e.g., death receptors, members of the Bcl2 family, caspases); (ii) ...
[66]Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, et al. (1999) Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner. J Cell Biol 144: 281–292. doi: 10.1083/jcb.144.2.281 ...
To detect the pathways of cell death, the levels of reactive oxygen species, cell viability, number of cells undergoing autophagy, apoptosis, and necrosis, the content of active caspases 3, 8, and 9 was fluorometrically measured in the irradiated 3D cell culture by laser scanning confocal ...