Caspase-9- dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2. Cell Tissue Res 2007;328:411-9.J.J. Lysiak, S. Zheng, R. Woodson, T.T. Turner, Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, bax,...
细胞凋亡(Apoptosis) 细胞凋亡有两条途径:内在途径(Intrinsic pathway)和外在途径(Extrinsic pathway)。 内在途径也称为线粒体途径,受BCL-2家族调控。在这一途径中,BCL-2家族成员BAX和/或BAK的激活允许凋亡效应因子渗透线粒体外膜,导致细胞色素c进入细胞质,并在此与APAF-1结合,触发凋亡小体的形成。该凋亡小体首先...
The p53 gene suppresses tumor cell growth by inducing cell cycle arrest or apoptosis. Loss of its apoptosis activity has been implicated not only in tumor development but also in chemoresistance. We previously reported that targeting p53 for degradation by the human HPV E6 gene in the ovarian can...
Mol Cell. 1998Jun;1(7):949-57.PubMed ID: 9651578 2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):9...
Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP). Caspase 9 is expr...
2、述。 关键词:Caspase;细胞凋亡 细胞凋亡的原词Apoptosis由两个拉丁字组成。Apo指离开,ptosis是落下,意思是细胞凋亡有如秋天落叶,到一定时候即失去生命力,遂即脱落,细胞凋亡,又称程序性细胞死亡(Programmed cell death,PCD)是机体生长发育、细胞分化和病理状态中细胞自主性死亡过程,是细胞内由基因编码调控的,按严格...
Therefore, caspase-9 mediates Puma activation to determine the threshold for overcoming chemoresistance in cancer cells. Cell Death and Disease (2014) 5, e1495; doi:10.1038/cddis.2014.461; published online 30 October 2014 The apoptosis pathway is closely related to the Bcl-2 family proteins in ...
《Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-4β signaling pathway》 作者:Baoquan Li,Xiaoguang Li 期刊:Biomedicine & Pharmacotherapy 影响因子:3.743 PMID:30142548 ...
2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):905-14.PubMed ID: 12181741 3. Swanton E,Savory P, Cosulich S, Clarke P, Woodman P.Bcl-2 re...
Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase 9 promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner, and proteolytically cleaves poly(ADP- ribose) polymerase (PARP). Caspase 9 is expressed in ...