3. Lin, Y., Devin, A., Rodriguez, Y. & Liu, Z. G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.Genes Dev.13, 2514–2526 (1999). 4. Feng, S. et al. Cleavage of RIP3 inactiv...
3. Lin, Y., Devin, A., Rodriguez, Y. & Liu, Z. G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis.Genes Dev.13, 2514–2526 (1999). 4. Feng, S. et al. Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase...
a member of the pore-forming gasdermin family, is dispensable for the secondary necrosis that follows NLRC4-mediated apoptosis in macrophages. Together, our data confirm the existence of an alternative caspase-8 activation pathway diverging from the NLRC4 inflammasome in primary macrophages...
ApoptosisCaspasesNeuronsParkinsonDiseaseSubstantiaNigra1-Methyl-4-phenyl-1Caspase-8 is a proximal effector protein of the tumor necrosis factor receptor family death pathway. In the present human postmortem study, we observed a significantly higher percentage of dopaminergic (DA) substantia nigra pars ...
Besides its proteolysis at the DISC, caspase-8 can also be activated downstream of mitochondria upon initiation of the intrinsic apoptosis pathway, e.g. via caspase-6 [21]. Recent evidence suggests that caspase-8 also has several non-apoptotic functions besides its well known role as a key ...
2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):905-14.PubMed ID: 12181741 3. Swanton E,Savory P, C...
2. Pirnia F,Schneider E, Betticher DC, Borner MM.Mitomycin C induces apoptosis andcaspase-8 and -9 processing through a caspase-3 and Fas-independent pathway.CellDeath Differ. 2002 Sep;9(9):905-14.PubMed ID: 12181741 3. Swanton E,Savory P, Cosulich S, Clarke P, Woodman P.Bcl-2 re...
关键词:当归拈痛汤;Fas/caspase-8 通路;类风湿关节炎;滑膜成纤维细胞;细胞凋亡 Danggui Niantong decoction induces apoptosis by activating Fas/caspase-8 pathway in rheumatoid arthritis fibroblast-like synoviocytes ZHAO Fan1, LI Jiayu1, LU Qijin1, CHEN Ensheng2, YUAN Lixia1 1School of Traditional ...
As caspase-8 is involved in apoptosis, including UV irradiation, we examined its activity after exposure to increasing doses of UVB and UVC in NHEK. We performed immunofluorescence on irradiated NHEK, using an antibody specific for the cleaved, active form of caspase-8, caspase-3 and caspase-...
Therefore, the apoptosis-induced mechanisms by ICD-85 are through activation of caspase-8 and concerning the least cytotoxic effect on MRC-5 cells, ICD-85 may be used as anticancer compound to inhibit growth of cancer cells. 展开 关键词: Caspase-8 Apoptosis Extrinsic pathway HeLa cells ...