Apoptosis PathwayJoza et al deleted exon 3 of the aif gene in mouse embryonic stem (ES) cells. This exon encodes the amino terminus of the protein, and because the aif gene is on the X chromosome, mutation of one aif allele resulted in a complete knockout in male ES cells. The ...
NF-κB signaling blocks NLRC4/caspase-8-dependent apoptosis pathway.Casp1−/−Casp11−/−BMDMs were pre-stimulated for with or without various stimuli – Pam3CSK4 (1 μg ml−1), LPS (1 μg ml−1), R837 (2 μg ml−1), TNFα (100 ng ml−1), IFN-α (1...
nuo-6) lead to increased longevity inC. elegans, which is mediated by mtROS. The intrinsic apoptosis pathway (CED-9, CED-4, and CED-3) is sensitive to mtROS and is utilized as a
细胞凋亡被认为是细胞更新,免疫系统的发育和功能,激素依赖性萎缩,胚胎发育和化学诱导细胞死亡等过程的重要组成部分。 Apoptosis is the process of programmed cell death characterized by distinct morphological characteristics and energy dependent biochemical mechanisms. Apoptosis is considered a vital component of pro...
Reversal of the Caspase-Dependent Apoptotic Cytotoxicity Pathway by Taurine from Lycium barbarum (Goji Berry) in Human Retinal Pigment Epithelial Cells: Po... Reversal of the Caspase-Dependent Apoptotic Cytotoxicity Pathway by Taurine from Lycium barbarum (Goji Berry) in Human Retinal Pigment Epithelial...
During animal development, the proper regulation of apoptosis requires the precise spatial and temporal execution of cell-death programs, which can include both caspase-dependent and caspase-independent pathways1,2. While the mechanisms of caspase-dependent and caspase-independent cell killing have been ...
After treatment of tanshinone IIA, caspase dependent apoptosis is observed in theosteosarcomaMG-63 cell line (including caspase-3, caspase-8, and caspase-9)[40], BT-20 human breast cancer cell line (including caspase-12, caspase-3)[41], 786-O humanrenal cell carcinomacells (caspase-3)[42...
参考细胞死亡命名委员会(NCCD)的分类,细胞死亡方式包括:内源性细胞凋亡(Intrinsic apoptosis)、外源性细胞凋亡(Extrinsic apoptosis)、坏死性凋亡(Necroptosis)、细胞焦亡(Pyroptosis)、铁死亡(Ferroptosis)、PARP1依赖的死亡(Parthanatos)、内亡或者侵入性细胞死亡(Entotic cell death)、依赖中性粒细胞外诱捕网的网补死亡(Ne...
Human papillomavirus(HPV) is mostly known to infect epithelial cells of the genital tract and cause cervical cancers. On epithelial differentiation, HPV induces a DNA damage response that leads to caspase 3-dependent apoptosis.24Interestingly, HPV E1, a protein involved in viral DNA replication, is...
Therefore, the apoptosis-induced mechanisms by ICD-85 are through activation of caspase-8 and concerning the least cytotoxic effect on MRC-5 cells, ICD-85 may be used as anticancer compound to inhibit growth of cancer cells. 展开 关键词: Caspase-8 Apoptosis Extrinsic pathway HeLa cells ...