Pharmacokinetics: time-dependent changes-autoinduction of carba- mazepine epoxidation. J Clin Pharmacol 1986;26:459-62.Bertilsson L, Tomson T, Tybring G (1986) Pharmacokinetics: time-dependent changes — autoinduction of carbamazepine epoxidation. J Clin Pharmacol 26:459–462...
This is called autoinduction and it takes three to five weeks of a fixed dosing regimen before it is complete. In children, plasma levels of carbamazepine poorly correlate with the dosage of carbamazepine. Carbamazepine is more rapidly metabolized in children to its active metabolite, which has ...
Carbamazepine can induce its own metabolism (autoinduction) after prolonged administration, decreasing its clearance rate, half-life, and serum concentrations. The possibility of autoinduction requires the clinician to reevaluate the patient’s blood levels after a month of carbamazepine therapy. The ...
Carbamazepineis extensively metabolized in the liver. After a single dose,t½,elimin plasma is around 30–40h, but because of “autoinduction” (carbamazepine induces its own metabolism),t½,elimmay fall to around 12h after long-termmonotherapy. Carbamazepine, as a potent enzyme inducer, is...
Autoinduction is completed after 3 to 5 weeks of a fixed dosing regimen. Initial half-life values range from 25 to 65 hours, decreasing to 12 to 17 hours on repeated doses. Carbamazepine is metabolized in the liver. Cytochrome P450 3A4 was identified as the major isoform responsible for ...
Important to initiate slowly by advancing dose every 5-7 days to minimizegastrointestinalupset and allow auto-induction of liver enzymes to occur (auto-induction is complete at 3-5 weeks) Children under 12 years who receive over 400 mg/day may be converted to CarbatrolERat the same dose, ev...
Carbamazepine substitution in severe partial epilepsy: implication of autoinduction of metabolism. 喜欢 0 阅读量: 18 作者:GJ Macphee,MJ Brodie 摘要: Established partial seizures are often refractory to treatment and many patients receive polypharmacy. An attempt was made to improve seizure control with...
(1984), Carbamazepine metabolism in man - Influence of auto and hetero-induction on some different oxidative pathways. Acta Neurologica Scandinavica, 69: 85–86. doi: 10.1111/j.1600-0404.1984.tb02398.x Author Information Department of Neurology, Söder Hospital, Stockholm, Department of Clinical ...
Autoinduction of carbamazepine metabolism in children examined by a stable isotope technique. Clinical Pharmacology and Therapeutics 27: 83–88, 1980 PubMed CAS Google Scholar Bertilsson L, Tomson T. Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide: ...
The history of the development of carbamazepine was outlined in an earlier volume in this series (Schmutz 1985). By that time, the drug had already been in clinical use for two decades and was a well established antiepileptic agent, with certain other us