多项临床研究已证实，CAR-NK细胞在治疗胶质母细胞瘤、肺癌、结直肠癌、胰腺癌、肝细胞癌、乳腺癌、卵巢癌等多款实体瘤方面具有可行性。尤其对于那些经常规手术或放化疗等传统治疗手段效果不佳的广泛转移或晚期患者而言，CAR-NK细胞无疑带来了新的选择与希望，下图展示了CAR-NK细胞在不同实体瘤中的探索实验。 ▲图...
[1]Wang W,et al.Breakthrough of solid tumor treatment: CAR-NK immunotherapy[J]. Cell Death Discovery, 2024, 10(1):40. https://www.nature.com/articles/s41420-024-01815-9 [2]Liu F,et al.Advances in CAR-NK ce...
与天然组织来源的NK细胞相比,利用人诱导性多能干细胞(human induced pluripotent stem cell,hiPSC)或人胚干细胞(human embryonic stem cell, hESC,来源于自然着床前囊胚中未分化的初始细胞)诱导分化制备的CAR-iNK细胞具有均一性高、成本低...
如果您对目前的治疗方案存疑,或想寻求CAR-NK细胞、NK细胞、CAR-T细胞等国内外其他抗癌新技术的帮助,可咨询医学部,详细评估病情或申请国内外抗癌专家会诊。 参考资料 [1]Wang W,et al.Breakthrough of solid tumor treatment: CAR-NK immunotherapy[J]. Cell Death Discovery, 2024, 10(1):40. https://www.n...
[2]Wang W,et al.Breakthrough of solid tumor treatment: CAR-NK immunotherapy[J]. Cell Death Discovery, 2024, 10(1): 40. https://www.nature.com/articles/s41420-024-01815-9 [3]https://www.cde.org.cn/main/xxgk/listpage/4b5255eb0a84820cef4ca3e8b6bbe20c...
2. CAR-NK Cell: a new paradigm in tumor immunotherapy, Frontiers in Oncology, 2021.3. Reimagining antibody-dependent cellular cytotoxicity in cancer: the potential of natural killer cell engagers. Trends Immunol, 2022.4. CAR-NK Cells: From Natural Basis to Designfor Kill. Front Immunol, ...
近日,世界知名期刊《Nature》子刊《Nature medicine》上报道了安德森癌症中心的研究人员通过“CAR-NK”细胞治疗血液肿瘤的I/II期惊艳的临床试验结果,也让人们看到了其在血液系统恶性肿瘤和难治性实体瘤领域的广阔应用前景! CAR19/IL-15 NK细胞未来可期,1年总生存率达68% ▲截图源自“nature medicine” 2017年6月30...
[2]Wang W,et al.Breakthrough of solid tumor treatment: CAR-NK immunotherapy[J]. Cell Death Discovery, 2024, 10(1): 40. https://www.nature.com/articles/s41420-024-01815-9 [3]https://www.cde.org.cn/main/xxgk/listpage/4b5255eb0a84820cef4ca3e8b6bbe20c...
相比于CAR-T , CAR-NK较短的生命周期减弱了 on target-off tumor毒性，不同的细胞因子表达谱降低了CRS和神经毒性发生的风险，NK细胞非MHC途径识别靶细胞的特性使异体CAR-NK发生GVHD的可能性降低。尽管如此，CAR-T所面临的主要挑战在CAR-NK上还是没有得到有效的解决。巨噬细胞作为TME中主要的免疫细胞，既有强大的...
[2]Wang W,et al.Breakthrough of solid tumor treatment: CAR-NK immunotherapy[J]. Cell Death Discovery, 2024, 10(1): 40. https://www.nature.com/articles/s41420-024-01815-9 [3]https://www.cde.org.cn/main/xxgk/listpage/4b5255eb0a84820cef4ca3e8b6bbe20c...