参考资料 [1]Zhang L,et al.CAR-NK cells for acute myeloid leukemia immunotherapy: past, present and future. Am J Cancer Res. 2023 Nov 15;13(11):5559-5576.https://pmc.ncbi.nlm.nih.gov/articles/PMC10695781/ [2]Liu E,et al.Use of CAR-transduced natural killer cells in CD19-positive ...
NK细胞即自然杀伤细胞(Natural killer cells),是从造血干细胞(HSC)分化而来的先天免疫细胞,在抵御病原体和癌细胞的一线防御中发挥着关键作用。 目前关于CAR的研究大多集中在T细胞,但事实上,NK细胞才是人体抗癌的种子选手,无需预先致敏,即可杀伤...
参考资料 [1]Marin D,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors:a phase 1/2 trial[J].Nature Medicine,2024: 1-13. https://www.nature.com/ar...
[1]Marin D,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+B cell tumors: a phase 1/2 trial. Nat Med. 2024 Mar;30(3):772-784.https://www.nature.com/articles/s41591-023-02785-8 [2]Sauter C S,et al.A Phase 1 Study of NKX1...
CAR-NK，全称为“嵌合抗原受体自然杀伤细胞”（Chimeric Antigen Receptor-Natural Killer Cells），听名字可能有点拗口，翻译过来就是“带着GPS导航的免疫杀手”。这是一种经过基因改造的NK细胞，它们被赋予了精准找到并摧毁癌细胞的能力，简直像古代游侠“路见不平拔刀相助”一般果断。相比于传统的CAR-T疗法，这些“...
CAR-NK疗法的临床研究表明，CAR-NK疗法血液癌和实体癌方面是非常有前途的。参考资料 Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors | NEJM 免责声明:免疫管家为免疫科普平台，文本参考来源于网络，版权归原作者所有。该文章仅供分享，如涉嫌侵犯您的著作权请联系我们删除，谢谢!
“肿瘤能让巨噬细胞支持生长,并把它们变成自己的爪牙。”Gill说。但是他和研究生Michael Klichinsky发现,用CAR装备巨噬细胞可以防止它们转换方向。 Engineered natural killer cells may be the next great cancer immunotherapy doi:10.1126/science.aav4154
【2】 Laskowski TJ, Biederstädt A, Rezvani K. Natural killer cells in antitumour adoptive cell immunotherapy. Nat Rev Cancer. 2022 Oct;22(10):557-575. 【3】 Liu E, Tong Y, Dotti G, Shaim H, Savoldo B, Mukherjee M, Orange J, Wan X, Lu X, Reynolds A, Gagea M, Banerjee P...
中科博生｜CAR-NK与CAR-T：有何不同？在免疫系统的奇妙世界里，T细胞和自然杀伤细胞（Natural Killer Cells, NK细胞）像是一对默契的搭档，共同守护着我们的身体健康。近年来，随着生物技术的发展，科学家们开发出了两种基于这两种细胞的先进免疫技术：CAR-T细胞和CAR-NK细胞。这两种技术在识别和攻击异常细胞方面都...
[5]Yang Y. Superior Expansion and Cytotoxicity of Human Primary NK and CAR-NK Cells from Various Sources viaEnriched Metabolic Pathways.Mol Ther Methods Clin Dev. 2020 Jun 24;18:428-445. [6]Ruyan Rahnama, Challice L. Bonifant; Engineering builds multipotency for iPSC-NKs.Blood2022; 140 (...