参考资料 [1]Zhang L,et al.CAR-NK cells for acute myeloid leukemia immunotherapy: past, present and future. Am J Cancer Res. 2023 Nov 15;13(11):5559-5576.https://pmc.ncbi.nlm.nih.gov/articles/PMC10695781/ [2]Liu E,et al.Use of CAR-transduced natural killer cells in CD19-positive ...
参考资料 [1]Marin D,,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+B cell tumors: a phase 1/2 trial. Nat Med. 2024 Mar;30(3):772-784. doi: 10.1038/s41...
[1]Marin D,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+B cell tumors: a phase 1/2 trial. Nat Med. 2024 Mar;30(3):772-784.https://www.nature.com/articles/s41591-023-02785-8 [2]Sauter C S,et al.A Phase 1 Study of NKX1...
CAR-NK cells: A promising cellular immunotherapy for cancer. EBioMedicine. 2020;59:102975. 赛业生物细胞治疗一站式解决方案 助力肿瘤免疫细胞治疗临床前研究 在CAR-T其他细胞治疗的临床前研究中,细胞模型、动物模型的选择都至关重要,明确研究的目的,建立有效的实验模型和方案,会使研究事半功倍。赛业生物提供细胞...
CAR-NK，全称为“嵌合抗原受体自然杀伤细胞”（Chimeric Antigen Receptor-Natural Killer Cells），听名字可能有点拗口，翻译过来就是“带着GPS导航的免疫杀手”。这是一种经过基因改造的NK细胞，它们被赋予了精准找到并摧毁癌细胞的能力，简直像古代游侠“路见不平拔刀相助”一般果断。相比于传统的CAR-T疗法，这些“...
[1]Marin D,et al.Safety,efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+B cell tumors: a phase 1/2 trial. Nat Med. 2024 Mar;30(3):772-784. https://www.nature.com/artic...
[2] Daher M, Basar R, Gokdemir E, et al. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells[J]. Blood, The Journal of the American Society of Hematology, 2021, 137(5): 624-636 [3] Rezvani K, Rouce R, Liu E, et al. Engineering natural kille...
2023年,国内研究团队在《干细胞研究与治疗》发表一篇题为“Intrathecal CAR-NK cells infusion for isolated CNS relapse after allogeneic stem cell transplantation: case report”的研究论文,文中介绍了CAR-NK治疗中枢神经系统(CNS)复发的白血病病例报告。
中科博生｜CAR-NK与CAR-T：有何不同？在免疫系统的奇妙世界里，T细胞和自然杀伤细胞（Natural Killer Cells, NK细胞）像是一对默契的搭档，共同守护着我们的身体健康。近年来，随着生物技术的发展，科学家们开发出了两种基于这两种细胞的先进免疫技术：CAR-T细胞和CAR-NK细胞。这两种技术在识别和攻击异常细胞方面都...
1.CAR-NK Cells in the Treatment of Solid Tumors.International Journal of Molecular Science.2021 2.Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients.Molecular Therapy.2019 3.Robo1-specific chimeric antigen receptor natural killer cell therapy for pancreatic...