The pivotal challenges in the field of solid tumor CAR T cell therapy can be summarized in three major parts: recognition, trafficking, and surviving in the tumor. On the other hand, the immunosuppressive tumor microenvironment (TME) interferes with T cell activity in terms of differentiation and...
Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell malignancies or relapsed and/or refractory multiple myeloma, yet efficacy against most solid tumours remains elusive. The limited imaging and biopsy data from clin
The adoptive transfer of T cells that are engineered to express chimeric antigen receptors (CARs) has shown remarkable success in treating B cell malignancies but only limited efficacy against other cancer types, especially solid tumours. Compared with haematological diseases, solid tumours present a un...
Few other factors, besides the differences in the chosen targets, might be responsible for failure of CAR-T cell therapies in solid tumors. The ACT in melanoma requires more cells, more profound lymphodepletion and the use of IL-2 support to obtain optimal results25,26,27. Furthermore, to e...
2023年10月，《Nature reviews clinical oncology》发布了宾夕法尼亚大学Steven M. Albelda教授撰写的题为“CAR T cell therapy for patients with solid tumours: key lessons to learn and unlearn”的综述文章，系统性地阐述了细胞治疗当前面临的困境——即CAR-T细胞在大多数实体肿瘤中的疗效仍然难以确定。Albelda...
实体瘤包含多种混合细胞,这些细胞在其表面显示不同的抗原,且很多抗原通常在健康细胞中也表达,因此,确定均匀表达、安全的靶点这一步就阻碍了大多数实体瘤CAR-T疗法的开发。 来源:Science 如何突破这一难题?10月12日发表在Science杂志上题为“Probiotic-guided CAR-T cells for solid tumor targeting”的一项研究中,...
他们设计了肿瘤定植细菌(益生菌),让定植在肿瘤中的它们产生合成靶标,从而引导 CAR-T 细胞消灭这些含有合成靶标的癌细胞。相关研究结果发表在2023年10月13日的Science期刊上,论文标题为“Probiotic-guided CAR-T cells for solid tumor targeting”。 图片来自Science, 2023, doi:10.1126/science.add7034。
近期,伊利诺伊大学芝加哥分校的刘颖教授团队与西北大学的张斌教授团队合作在《Journal of Controlled Release》期刊2023年第362期发表了题为 “Toroidal-spiral particles as a CAR-T cell delivery device for solid tumor immunotherapy”的研究论文。 自从嵌合抗原受体T...
Vile 研究组在Science Translational Medicine上发表题为Oncolytic virus–mediated expansion of dual-specific CAR T cells improves efficacy against solid tumors in mice的文章,改进了上述CAR T疗法。 首先,作者之前的工作采用小鼠黑色素瘤模型,在转输CAR T细胞之前瘤内注射溶瘤病毒(VSV-mIFN)。作者发现注射溶瘤...
8)L. Cherkassky et al., “Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition,” J Clin Invest, 126:3130–44, 2016. 9)O.O. Yeku et al., “Armored CAR T cells enhance antitumor ef...