Conclusion Nowadays, identifying and defeating the mechanisms associated with CAR T cell dysfunction is crucial to establish CAR T cells that can proliferate and lyse tumor cells severely. In this review, we discuss the CAR signaling and efficacy T in solid tumors and evaluate the most significant...
Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell malignancies or relapsed and/or refractory multiple myeloma, yet efficacy against most solid tumours remains elusive. The limited imaging and biopsy data from clin
The adoptive transfer of T cells that are engineered to express chimeric antigen receptors (CARs) has shown remarkable success in treating B cell malignancies but only limited efficacy against other cancer types, especially solid tumours. Compared with haematological diseases, solid tumours present a un...
But, their efficacy in solid tumor treatment has not yet been supported. The pivotal challenges in the field of solid tumor CAR T cell therapy can be summarized in three major parts: recognition, trafficking, and surviving in the tumor. On the other hand, the immunosuppressive tumor ...
然而,在实体瘤中CAR - T细胞对表达靶抗原的非肿瘤组织的识别,往往导致临床严重的非肿瘤靶向毒性,简称OTOT(on target, off-tumor toxicity)。当前有多种正在开发的用于提高实体肿瘤中CAR - T细胞特异性并减轻临床OTOT风险的巧妙设计,具体干货请看下...
T therapy for solid tumors, yet the response rate has been unsatisfactory thus far [5], mainly due to the low specificity and high heterogeneity of tumor antigens, the immunosuppressive tumor microenvironment (TME), as well as limited T-cell infiltration and persistence [6]. This review ...
T cells to infiltrate the tumor, insufficiency of T cell recruitment to the tumor site due to abnormal chemokines secreted by solid tumor cells and to the immunosuppressive tumor microenvironment [26,27]. Moreover, other limitations are related to CAR-T cell side effects including the on-target...
IMPROVING CEA-TARGETED CAR-T CELL THERAPY FOR SOLID TUMOURS W Zheng,G Kueberuwa,E Cheadle,... - 《Human Gene Therapy》 被引量: 0发表: 2019年 Homing to solid cancers: a vascular checkpoint in adoptive cell therapy using CAR T-cells The success of adoptive T-cell therapies for the ...
近期,伊利诺伊大学芝加哥分校的刘颖教授团队与西北大学的张斌教授团队合作在《Journal of Controlled Release》期刊2023年第362期发表了题为 “Toroidal-spiral particles as a CAR-T cell delivery device for solid tumor immunotherapy”的研究论文。 自从嵌合抗原受体T...
植入式肿瘤模型(implantable tumor models); 基因工程小鼠模型(genetically engineered mouse models,GEMMs); 人源化小鼠模型(humanized mouse models,HM models) 1 植入式肿瘤模型 这是目前肿瘤免疫治疗临床前研究中应用最广泛的免疫功能模型。这些模型是通过向具有免疫能力的宿主注射同源的组织相容性肿瘤细胞而建立的。其...