This review article highlights currently active clinical trials and a few pertinent preclinical studies involving CAR Tcell therapy in solid tumors while briefly discussing study outcomes and potential key targets that may allow for the feasibility of this therapy option. Finally, we mention critical ...
靶向CD19或B细胞成熟抗原的嵌合抗原受体(CARs)T细胞疗法已被批准用于治疗某些B细胞恶性肿瘤。然而,在实体瘤中CAR - T细胞对表达靶抗原的非肿瘤组织的识别,往往导致临床严重的非肿瘤靶向毒性,简称OTOT(on target, off-tumor toxicity)。当前有多种...
Nevertheless, the utilization and effectiveness of CAR-T cell therapy in solid tumors are still limited primarily because of the absence of tumor-specific target antigen, the existence of immunosuppressive tumor microenvironment, restricted T cell invasion and proliferation, and the occurrence of severe ...
[1] Upadhaya S, Partridge T, Monica S et al. Landscape of cancer cell therapies: trends and real-world data. Nat Rev Drug Discovery. 2022 [2] Urvi P, John A, Bipin N et al. CAR T cell therapy in solid tumors: A review of current clinica...
Nowadays, identifying and defeating the mechanisms associated with CAR T cell dysfunction is crucial to establish CAR T cells that can proliferate and lyse tumor cells severely. In this review, we discuss the CAR signaling and efficacy T in solid tumors and evaluate the most significant barriers ...
Here, we review protein- and cell-engineering strategies that seek to overcome these obstacles and produce next-generation T cells with enhanced tumour specificity and sustained effector function for the treatment of solid malignancies. This is a preview of subscription content, access via your ...
In this review, we will discuss the current stats and challenges of CAR-T cell therapy for solid tumors, and propose possibl e solutions and future perspectives. 展开 关键词: chimeric antigen receptor T cells cancer adoptive cell transfer tumor microenvironment ...
Solid cancers present some formidable barriers to adoptive cell transfer, including suppression of T-cell function and inhibition of T-cell localization. In this review, we discuss the current state of CAR T-cell therapy in solid cancers, the variety of concepts being investigated to overcome ...
CAR-T in solid TME- Abstract and Intro 2022-01-18 13:28:3305:50 9 所属专辑:外泌体 喜欢下载分享 声音简介Navigating CAR-T Cells through the solid tumor microenvironment- Abstract and IntroNature Reviews Drug DiscoveryAndrew Hou, Laurence Chen, and Yvonne Chen10 May 2021...
This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR influence signalling and function. We report...