具体来说,在这项研究中,Danino的实验室开发出了一种可以靶向通用抗原的通用型CAR-T,这些抗原是通过工程细菌“涂”在实体瘤表面的(工程改造一种非致病性大肠杆菌菌株,使之将合成抗原传递到肿瘤微环境并“标记”肿瘤),之后CAR识别这些抗原,攻击肿瘤。 这种益生菌引导的CAR-T细胞(probiotic-guided CAR-T cell, ProCA...
report that CAR Tcell activity against solid tumors depends on cell adhesion mediated by IFN纬 signaling, opening the prospect of improving their clinical activity in the future.doi:10.1016/j.medj.2022.05.009Matthew.BellDepartment of Bone Marrow Transplantation and Cellular Therapy, St. Jude ...
10月12日发表在Science杂志上题为“Probiotic-guided CAR-T cells for solid tumor targeting”的一项研究中,来自哥伦比亚大学的科学家们报告一种创新策略。他们设计了肿瘤定植细菌(益生菌),在肿瘤中产生合成抗原,指导CAR-T细胞摧毁被迫“露脸”的癌细胞。 “我们的益生菌平台使CAR-T细胞能够攻击各种类型的肿瘤。传统...
Chimeric antigen receptor (CAR) T cells have been approved for use in patients with B cell malignancies or relapsed and/or refractory multiple myeloma, yet efficacy against most solid tumours remains elusive. The limited imaging and biopsy data from clin
这种益生菌引导的CAR-T细胞(probiotic-guided CAR-T cell, ProCAR)平台是这些作者首次成功地将经过基因改造的益生菌与CAR-T细胞结合在一起,而且还首次证明了CAR-T细胞对直接在肿瘤内产生的合成抗原有反应。 论文共同第一作者、Danino实验室博士生Rosa Vincent说,“将靶向肿瘤的细菌和CAR-T细胞结合在一起的优势,提供...
[3] CAR T-cell therapy for solid tumors. Lancet Oncol 2021; DOI: 10.1016/S1470-2045(21)00353-3. https://pubmed.ncbi.nlm.nih.gov/34197740/ [4] Narayan Vivek,Barber-Rotenberg Julie S,Jung In-Young et al. PSMA-tar...
各种精确和可控的方案是目前正在修改CAR结构。而且,临床前模型中的组合治疗策略已经成功,表明了转化为临床应用的潜力,并且将来需要更多的临床研究来评估组合疗法的效果。 ~Am J Cancer Res 2020;10(7):1979-1992,<Innovative strategies to advance CAR T cell therapy for solid tumors>...
~Am J Cancer Res 2020;10(7):1979-1992,<Innovative strategies to advance CAR T cell therapy for solid tumors> 识别微信二维码,添加生物制品圈小编,符合条件者即可加入生物制品微信群! 请注明:姓名+研究方向! 版 权 声 明
Retrieved May 25, 2021, from https://endpts.com/researchers-in-biotech-academia-and-big-pharma-are-offering-puzzle-pieces-to-crack-car-t-for-solid-tumors-will-they-ever-snap-together/ [3] Hawkins et al., (2021). Armored CAR T-Cells: The Next Chapter in T-Cell Cancer Immunotherapy. ...
CAR-T cell therapies are currently only approved for blood cancers, but new preclinical research shows promise in using CAR-T cells against solid tumors in gastric cancer. CAR-T Cell Therapy for Solid Tumors? CAR-T cell therapy is already a promising cancer treatment strategy, with FDA ...