In oncology, the term 'targeted therapy' is used to describe drugs that target only the cancer cells and spare normal cells thereby reducing host toxicity while simultaneously increasing the eradication of cancer. Trastuzumab and imatinib are well known examples of successful targeted therapy. Newer ...
Thus far, several targeted treatments, each directed at a specific cancer trait, have been approved for clinical use. A few examples are outlined: (1) targeting of specific cell signaling pathways such as the epidermal growth factor inhibitors—cetuximab (Erbitux), a chimeric (mouse/human) monocl...
The early clinical inspiring results of these agents have built the foundation and examples for development newer generations of targeted therapies and ushered a modern field of cancer therapy. 展开 关键词: cancer targeted therapies efficacy 年份: 2003 ...
Targeted therapy. This therapy uses a special chemotherapy drug that only kills cancer cells with a certain trait. For instance, targeted therapy would work on a person's lung cancer only if the cancer cells contained that specific target.Prognosis...
In contrast to conventional cytotoxic chemotherapy and radiation therapy, a new method of targeted cancer therapeutics is being directed towards molecular pathways that underlie the malignant phenotype. These therapies target specific tumor cell receptors or signaling events that are critical to tumor progre...
Fig. 2: Pathways offering potential sites for targeted therapy. CRC: colorectal cancer; VEGF/VEGFR: vascular endothelial growth factor/vascular endothelial growth factor receptor; EGF/EGFR: epidermal growth factor/epidermal growth factor receptor; HGF: hepatocyte growth factor; c-MET: mesenchymal–epithe...
survival.256Examples of such small-molecule compounds are selective tyrosine kinase inhibitors.257Selective small-molecule inhibitors have less severe side effects than standard chemotherapy, but both types of therapy can lead to therapy resistance and relapse, as some cells within the heterogeneous tumor...
Here we review recent advances and controversies in the therapy of hereditary cancers (Table 1). Table 1 Examples of cytotoxic and targeted drugs showing promising activity towards hereditary cancers Full size table BRCA1 and BRCA2 Therapeutic window in BRCA-driven tumors Breast-ovarian hereditary ...
Using these as examples, many of the innovations and challenges in the treatment of women with breast cancer are explored. 展开 关键词: Breast cancer Targeted therapy Biomarkers Chemotherapy Angiogenesis Her2 DOI: 10.1007/s10585-012-9496-y 被引量: 97 ...
Table 1 Examples of targeted molecular cancer therapeutics receiving marketing approval by the US FDA 2001–2006 Year Examples of targeted molecular therapeutics Drug type Disease indication Primary molecular target 2006 Sprycel (dasatinib) Small molecule Gleevec-resistant CML BCR-ABL, SRC Sutent (...