Targeted or biological therapies seek to treat cancer and boost the body's immune system while minimizing damage to normal, healthy cells. Monoclonal antibodies, immunomodulating drugs, vaccines, and cytokines
Using these targets the drug disables the cancer cells, so they cannot spread, and on the other side, normal cells can survive.Targeted therapy drugs work in a few different ways. They may turn off the process in cancer cells that causes them to grow and spread, making cancer cells die ...
In addition, the limited repertoire of available drugs has made it difficult to exploit these differences for different treatment strategies.BerndGronerGroner B. Introduction: The rationale for the development of targeted drugs in cancer therapy. Recent Results Cancer Res 2007; 172:1‑3....
Targeted therapy(靶向治疗)uses drugs to stopcancer from growing and spreading. It's a newfor all patients with cancer. At the same time,effective way that is better than other treatmentsdifferent cancers may have the same target.chemotherapy according to the text?With the development of targeted...
survival.256Examples of such small-molecule compounds are selective tyrosine kinase inhibitors.257Selective small-molecule inhibitors have less severe side effects than standard chemotherapy, but both types of therapy can lead to therapy resistance and relapse, as some cells within the heterogeneous tumor...
The first wave of genetically targeted therapies for cancer focused on drugging gene products that are recurrently mutated in specific cancer types. However, mutational analysis of tumours has largely been exhausted as a strategy for the identification o
for delivery of siRNA as a standalone therapy may not fulfill all requirements of LC management, combining siRNAs and chemotherapeutic drugs/inhibitors using novel nanomedicine-based drug delivery systems would benefit the field of personalized medicine and provide patient specific siRNA-targeted therapies...
Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therapy. Medical management is often associated with the development of treatment resistance leading ...
Editor 1 - Clinical Oncologist: Focus on the clinical applications of drug repurposing in cancer treatment, including the integration of repurposed drugs into existing therapeutic regimens and the impact on patient outcomes. Editor 2 - Pharmacologist: Concentrate on the pharmacological aspects of drug ...
However, chemotherapy is accompanied by pain, immunocompromise and other adverse reactions, and the repeated application of chemotherapy drugs easily produces drug resistance and leads to tumour recurrence [3], [4]. Although molecular targeted therapy has achieved certain results, single blockade of ...