Targeted therapy for oncogenic addiction involves identification of the oncogene specific to a cancer and inhibiting the activity of the proteins it encodes. Most of the targeted therapies for oncogenic addiction are small-molecule inhibitors, which bind to cell proteins and block their activity. Target...
Gatzemeier, "Targeted therapies: thalidomide in lung cancer therapywhat have we learned?" Nature Reviews Clinical Oncology, vol. 7, no. 3, pp. 134-135, 2010.Reck M, Gatzemeier U. Targeted therapies: thalidomide in lung cancer therapy - what have we learned? Nat Rev Clin Oncol. 2010;7...
If the cancer is caught soon enough (before node involvement and metastasis occur), there is a strong chance of survival; however, only slightly more than one third of cases are detected that soon. Emerging treatments that target only the cancer cells are increasing the length of survival for...
Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules ("molecular targets")
The left breast is uninvolved. The physician is concerned that she may have inflammatory breast cancer.关键词: chemotherapy inflammatory breast cancer radiotherapy surgery targeted therapies treatment DOI: 10.1517/14656560903401638 被引量: 3 年份: 2009 ...
Once mesothelioma cancer is diagnosed, doctors can determine the best treatments based on its location, stage, and cell type. Avoiding a Misdiagnosis Mesothelioma often gets mistaken for pneumonia or other types of cancer. In fact, 22.6% or nearly 1 in 4 cases are misdiagnosed, according to a...
Precision medicine has transformed cancer care, particularly in cancers like breast, lung, and melanoma, where targeted therapies guided by genetic profiling are now routine for patients who can afford it. Research andclinical trialscontinue to expand the reach ofprecision medicine, promising more effec...
This year, we’ll celebrate 10 years since cancer immunotherapy was recognized as the “breakthrough of the year”by Science magazinein 2013. Over 30 cancers are treatable with immunotherapy and thegoal of the awareness monthis to increase this number further and bring life-saving therapies to ...
A recent report released by Cancer Research UK1noted that people living in more deprived areas of the UK are more likely to get cancer, accounting for 20,000 extra cancer cases each year. This disparity, in part, stems from smoking rates and obesity, both of which are higher in deprived ...
Figure 1. On-target vs off-target effects of T-type calcium channel (TTCC) blockers used in cancer cells. Selective inhibition of TTCCs (indicated by white cross on inner mouth of channel) inhibits all Ca2+-dependent pathways in their signaling domain. Switched-off effectors/pathways are repr...