Cancer is one of the most common causes of death, taking nearly 7 million lives each year worldwide. New cancer targeted therapies that make use therapeutic antibodies or small molecules have made treatment more tumor-specific and less toxic. Nevertheless, there remain several challenges to the ...
the tumors returned, and Sarah traveled back to Boston for further drug treatment, which was not successful. She developed brainmetastases[mə'tæstəsi:z].Her doctors in Boston knew of one more targeted therapy drug...
The era of “targeted therapy” was heralded by the approval of the antibodies Rituximab and Trastuzumab for the treatment of relapsed or refractory low-grade follicular B-cell non-Hodgkin’s lymphoma and Her2/Neu-positive metastatic breast cancer, respectively [1, 2]. The use of small molecule...
Introduction Cancer is one of the leading cause of morbidity and mortality worldwide. There are several therapies; however, most of them harm both healthy and cancerous cells. Proteolysis-targeting chimaeras (PROTACs) can be utilized as a targeted cancer treatment. These small molecules known as ...
Common to all these targeted therapies is their interaction with defined molecules present on cancer cells, which adds various degrees of increased selectivity to their toxic effects. As a consequence, detecting the target molecule on tumors before therapy holds great diagnostic potential for predicting...
they know the side effects of the treatmentC. they have the right targets of the cancercellsD.they suffer from early-stage cancers31. What's the author's purpose of wrting the text?A. To introduce a new treatment for cancer.B. To describe the populaity oftargeted therapy.C. To compar...
both of which are FDA approved in HER-positive breast cancer treatment, helped patients with HER2-amplified metastatic CRC to gain an overall response rate of 32%, a PFS of 2.9 months and an OS of 11.5 months, which may be even better in patients with RAS-wild-type CRCs (PFS: 5.3 mont...
Iconography : Targeted therapies for the treatment of cancer Therapeutic resistance remains a major cause of cancer-related deaths. Resistance can occur from the outset of treatment or as an acquired phenomenon after... JA Kim 被引量: 99发表: 2003年 Fc receptor-targeted therapies for the treatmen...
Targeted treatment modalities for skin cancerHauschild, A.Free Access Author Information Department of Dermatology, University of Kiel, Germany The evidence-based treatment of primary skin cancer is uncomplicated in the majority of cases. Typically, surgery is the therapy of choice. However, in more ...
targeting oncogenic viral proteins to treat related tumors, supporting the development of further comprehensive treatment regimens. Given their critical function in oncogenesis and the fact that patients share them, these neoantigens continue to be desirable targets for cancer immunotherapy.21,221,222,...