Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules ("molecular targets")
What is targeted therapy for oncogenic addiction in cancer? Targeted therapy for oncogenic addiction involves identification of the oncogene specific to a cancer and inhibiting the activity of the proteins it encodes. Most of the targeted therapies for oncogenic addiction are small-molecule inhibitors, ...
Targeted therapies in breast cancer (especially those targeting the estrogen receptor and HER-2) have transformed the face of this disease over the past generation.The very term "targeted therapy" raises questions deserving of our consideration. What do we mean by targeted therapy? Functionally, ...
If the cancer is caught soon enough (before node involvement and metastasis occur), there is a strong chance of survival; however, only slightly more than one third of cases are detected that soon. Emerging treatments that target only the cancer cells are increasing the length of survival for...
The emergence of new novel therapeutic agents which directly target molecules that are uniquely or abnormally expressed in cancer cells (molecular targeted therapy, MTT) has changed dramatically the treatment of cancer in recent years. The clinical benefit associated with these agents is typically limite...
Targeted Antibodies:Use monoclonal antibodies against cancer-specific antigens. The antibody can be monospecific, bispecific, or conjugated to a cytotoxic drug. Oncolytic Virus Therapy:Modifies a virus to specifically infect and kill cancer cells without affecting non-cancerous cells. The US Food and...
Combining Targeted Therapies and Drugs with Multiple Targets in the Treatment of NSCLC The first generation of clinical trials of targeted agents in non-small cell lung cancer (NSCLC) treatment has concluded. To date, only a few of these new ... Maione,P. - 《Oncologist》 被引量: 163发表...
Ovarian cancer is the second most common gynaecological malignancy and the leading cause of death from gynaecological cancer. Although in some cases treatm... BS Kaye - 《European Journal of Cancer》 被引量: 100发表: 2011年 Clinical trials and future potential of targeted therapy for ovarian canc...
Cancer Research UK. “Moreover, if funding is only given to a homogenous group of researchers sharing similar backgrounds, we risk asking a similar set of scientific questions. Diversity in the workplace brings new perspectives to current problems and fosters diverse thinking in research as well....
Thus, IHC is no longer recommended, and FISH is used less and less, notably for lung cancer [151]. Targeted RT-PCR approaches are no longer used and have been replaced by multiplex RT-PCR methods as well as by DNA- and RNA-based NGS or even multiplex analytical techniques on the Nano...