C-type lectin-like receptor 2 (CLEC-2) has been identified as a receptor for a platelet-activating snake venom, rhodocytin. CLEC-2 elicits powerful platelet activation signals in a manner dependent on Src, Syk kinases, and phospholipase C纬2, similar to the collagen receptor glycoprotein (...
内容提示: Chapter 6C-Type Lectin-Like Receptor 2 (CLEC-2)Katsue Suzuki-InoueAbstract C-type lectin-like receptor 2 (CLEC-2) has been identif i ed as a receptorfor a platelet-activating snake venom, rhodocytin. CLEC-2 elicits powerful plateletactivation signals in a manner dependent on ...
C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity. Eur J Immunol 1998;28:1134-1142....
The Dectin-2 family of C-type lectin-like receptors: an update New discoveries reveal crucial roles for the Dectin-2 family in many aspects of the immune response.Myeloid and non-myeloid cells express members of the C-... K Bernhard,JA Willment,GD Brown - 《International Immunology》 被引...
Galectin-3 has also been shown to associate with TLR-2, and the data indicate that it plays asimilar role in The fungal pattern recognition receptor, Dectin-1, and the associated cluster ofC-type lectin-like receptors. Dectin-1 is a major beta-glucan receptor on macrophages. doi...
C-type lectin-like receptor-2 (CLEC-2) is a member of the C-type lectin superfamily of cell surface receptors. The first confirmed endogenous and exogenous ligands of CLEC-2 are podoplanin and rhodocytin, respectively. CLEC-2 is expressed on the surface of platelets, which participates in...
C-type lectin receptors (CLRs) comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. The lectin activity of these receptors is mediated by conserved carbohydrate-recognition domains (CRDs). On the basis of their molecular structure, two groups of membrane-...
PRRs include the archetypical Toll‑like receptors (TLRs), as well as non‑TLRs such as intracellular nucleotide‑ binding domain and leucine‑rich‑repeat‑containing family (NLRs), retinoic acid‑inducible gene I (RIG‑I)‑ like receptors and C‑type lectin receptors (CLRs)2. ...
Among them, those expressed on phagocytes and working as pathogen pattern-recognition receptors were designated as C-type lectin receptors (CLRs), in accordance with Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I–like receptors (RLRs). Most of the genes for CLRs are ...
C-type lectins and C-type lectin-like receptors are involved in a multitude of biological processes, including cell migration, antigen uptake and presentation and cell adhesion. Recently, it has been shown that the C-type lectins Langerin and DC-SIGN are preferentially produced by DCs. Langerin ...