C-type lectin like receptors (CLRs), play an important role in immune functions of the organisms. In chicken, B-NK and B-Lec genes encode CLRs that contain C-type lectin like domain. Polymorphism in CDS of B-NK and B-Lec genes were investigated in Ghagus, Nicobari and W...
C-type lectin receptors (CLRs) comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. The lectin activity of these receptors is mediated by conserved carbohydrate-recognition domains (CRDs). On the basis of their molecular structure, two groups of membrane-...
与真菌感染相关的CLRs家族主要有:树突状细胞相关性C型凝集素受体(DC-associated C-type lectin receptors,Dectin),包括Dectin-1、Dectin-2、Dectin-3、巨噬细胞诱导的C型凝集素受体(macrophage inducible C-type lectin receptors,Mincle);抑制性CLRs,包括树突状细胞抑制性受体(DC inhibitory receptor,DCIR)、Clec2a...
PRRs include the archetypical Toll‑like receptors (TLRs), as well as non‑TLRs such as intracellular nucleotide‑ binding domain and leucine‑rich‑repeat‑containing family (NLRs), retinoic acid‑inducible gene I (RIG‑I)‑ like receptors and C‑type lectin receptors (CLRs)2. ...
The C-type lectin receptors (CLRs) belong to a large family of proteins that contain a carbohydrate recognition domain (CRD) and calcium binding sites on their extracellular domains. Recent studies indicate that many CLRs, such as Dectin-1, Dectin-2 and Mincle, function as pattern recognition ...
C-type lectin-like receptors (CLRs) agonists[+3] 在研机构 Bolt Biotherapeutics, Inc. 原研机构 Bolt Biotherapeutics, Inc. 在研适应症 结直肠癌[+7] 非在研适应症- 最高研发阶段临床1/2期 首次获批国家/地区- 首次获批日期1800-01-20 1
CLRs are a group of transmembrane proteins with one or more carbohydrate recognition domains (CRDs) or C-type lectin-like domains (CTLDs) that are involved in calcium-dependent recognition of pathogen surface carbohydrates [21]. From: Non-coding RNA Research, 2023 ...
C-type lectin receptors (CLRs) comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. CLRs include the Dendritic cell-associated C-type lectin-1 (Dectin-1), Dectin-2, macrophage-inducible C-type lectin (Mincle), DC-specific intercellular adhesion molecule...
Among them, those expressed on phagocytes and working as pathogen pattern-recognition receptors were designated as C-type lectin receptors (CLRs), in accordance with Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-I–like receptors (RLRs). Most of the genes for CLRs are ...
Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is important not only for antigen presentation, but also for the induction of appropriate adaptive immune responses via T helper (TH) cell differentiation. CLRs act either by themselves or in cooperation with other ...