[3]Litton JK, Rugo HS, Ettl J, et al. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation[J]. N Engl J Med. 2018, 379(8):753-763. [4]Fasching PA, Link T, Hauke J, et al. Neoadjuvant paclitaxel/olaparib in comparison to paclitaxel/carboplatinum in p...
[3]Litton JK, Rugo HS, Ettl J, et al. Talazoparib in patients with advanced breast cancer and a germline BRCA mutation[J]. N Engl J Med. 2018, 379(8):753-763. [4]Fasching PA, Link T, Hauke J, et al....
(Kuchenbaecker K B, Hopper J L, Barnes D R, et al. Risks ofbreast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers[J]. Jama, 2017, 317(23): 2402-2416.) 在这9856名女性中,有4810名女性在登记的时候已经发生了乳腺癌和/或卵巢癌,同时有一部分女性进行了预防性...
BRCA1/2 mutation in breast cancer: biological aspects, patterns of care and impact on outcome in a monoinstitutional cohortChemotherapy-induced peripheral neuropathy (CIPN) is a major clinical problem associated with a number of cytotoxic agents. OPERA (GAMFARMA srl, Milan, Italy) is a new ...
BRCA基因,全称“乳腺癌易感基因”(Breast Cancer Gene),包括两个基因:BRCA1和BRCA2,分别位于人类染色体17q21上和13q12上,是与卵巢癌和乳腺癌发生密切相关的抑癌基因,就像体内细胞的“修理工”,能生产肿瘤抑制蛋白,专门负责修复损伤的双链DNA,细胞周期调控等,并及时修复“生病”的细胞,避免其进一步发展为肿瘤细胞。
Myers SP, Sevilimedu V, Barrio AV, Tadros AB, Mamtani A, Robson ME, Morrow M, Lee MK. Pathologic complete response after neoadjuvant systemic therapy for breast cancer in BRCA mutation carriers and noncarriers. NPJ Breast Cancer. 2024 Jul 26;10(1):63. doi: 10.1038/s41523-024-00674-y...
2.Breast cancer gene does not boost risk of death: study 3.Breast cancer in young women: do BRCA1 or BRCA2 mutations matter? 4.Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study 转化医学领域核心...
谈起BRCA1和BRCA2基因(Breast Cancer Susceptibility)相信大家都有所了解,这是早在20世纪初就被证实直接与遗传性乳腺癌有关的基因,拥有该突变的人群患乳腺癌的概率更高。 后续,让这两个基因与乳腺癌的关联更为人所知的,应该是好莱坞红星安吉丽娜﹒朱莉,她因为家族乳腺癌病史、自身BRCA1基因突变,接受了预防性的双侧...
[11]Robson M, Im S A, Senkus E, et al. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation[J]. New England Journal of Medicine, 2017, 377(6): 523-533. [12]National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®...
1.认识你的基因:BRCA1和乳腺癌 2.Breast cancer gene does not boost risk of death: study 3.Breast cancer in young women: do BRCA1 or BRCA2 mutations matter? 4.Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study...