1.第一项研究是一项meta分析,关于BRCA突变对乳腺癌预后影响的研究有很多,结果也不完全一致,我选择这项研究的原因有两个:第一个是这项研究的发表日期是2021年;第二个是研究发表在Breast cancer research and treatment这个杂志上,是乳腺癌领域的老牌杂志。 (Liu M, Xie F, Liu M, et al. Association between ...
[11]Robson M, Im S A, Senkus E, et al. Olaparib for metastatic breast cancer in patients with a germline BRCA mutation[J]. New England Journal of Medicine, 2017, 377(6): 523-533. [12]National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®...
10. Robson ME,Tung N,Conte P,et al. OlympiAD final overall survival and tolerability results:olaparib versus chemotherapy treatment of physician’s choice in patients with a germline BRCA mutation and HER2-negative metastatic breast cancer[J]. Ann ...
Treatment for Metastatic Breast Cancer With BRCA-Mutationdoi:10.1097/01.COT.0000530899.56555.36Lippincott Williams and WilkinsOncology Times
BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010;31(6):961-967. doi:10.1093/carcin/bgq069 [7] Grinda T, Delaloge S. BRCA2: a 25-year journey from gene identification to targeted cancer treatment. ...
检索的英文数据库为PubMed和Embase,中文数据库包括中国生物医学文献数据库、中国知网和万方数据库,检索时限起始于1990年1月,截至2023年8月,英文文献检索词主要包括BRCA1/2、hereditary breast cancer、hereditary ovarian cancer、germline mu...
Sometimes BRCA2 mutations, but it's unusual to have a BRCA1 mutation. I look for reasons to test, and I’m careful about those patients in whom testing is not done. Your patient who's over the age of 65 with zero family history and an ER-positive small tumor is not going to be ...
BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates... E Levy-Lahad,E Friedman - 《British Journal of Cancer》 被引量: 492发表: 0年 BRCA1 and BRCA2 Mutation Frequency in Women Evaluated in ...
For the first time, testing for a germline mutation that predisposes to cancer has the potential to influence the immediate surgical, radiotherapeutic, and drug treatment choices of an individual with a new diagnosis of breast cancer. In this Review, we examine the implications of moving germline...
BRCA基因突变分为两类:一类为胚系突变(germline mutation,gBRCAmut),由精子或卵母细胞的生殖细胞突变,使机体所有细胞都带突变,可遗传;另一种为体细胞突变(somatic mutation,sBRCAmut),发生于肿瘤细胞中的BRCA基因突变,为非遗传性。截至2017年12月,乳腺癌信息中心(Breast Cancer Informationcore,BIC)报道约1800个BRCA1...