BRCA1andBRCA2are tumor suppressor genes that have been linked to inherited susceptibility of breast cancer. GermlineBRCA1/2pathogenic or likely pathogenic variants (gBRCAm) are clinically relevant for treatment selection in breast cancer because they confer sensitivity to poly(ADP-ribose) polymerase (PA...
乳腺癌易感基因(breast cancer susceptibility gene, BRCA)与乳腺癌有着密不可分的关系。BRCA基因的两个成员,即BRCA1和2,分别是在1990年和1994年被分离。 乳腺癌可以分为遗传性乳腺癌和散发性乳腺癌(sporadic breast cancer),散发性乳腺癌指的是没有发现明确的遗传基因改变(完整的癌变点)与乳腺癌家族史的乳腺癌...
The article advises women about the association between breast cancer (BC) and the presence of a mutation in BC susceptibility gene 1 or 2 (BRCA1/2). Diagnosis of the presence of a BRCA mutation involves genetic testing of a small blood sample. According to the authors, women who have ...
BRCA基因的英文全称是breast cancer susceptibility gene,也叫做乳腺癌易感基因,包括BRCA1和BRCA2,其中BRCA1基因位于第17号染色体,BRCA2基因位于第13号染色体。它们是重要的抑癌基因,其编码产物参与了DNA损伤同源性重组修复(Homologous Recombination Repair, H...
做了这么多的铺垫,终于到了我们的“正餐”——BRCA基因,BRCA基因是Breast Cancer Gene的简称,中文意为乳腺癌基因。 而在浩如烟海的人类基因之中,其发现人玛丽-克莱尔·金(Mary-ClaireKing)于1990年首次定位到了在第17号染色体上的BRCA1基因,不久之后人们又发现了位于13号染色体上的BRCA2基因。
BRCA 基因全称为乳腺癌易感基因(breast cancer susceptibility gene,BRCA),主要有两种类型:BRCA1、BRCA2,分别在 1990 年和 1994 年研究遗传性乳腺癌相关病因时被发现。 BRCA1/2 基因均在 DNA 损伤修复、细胞的正常生长方面发挥重要作用,具有抑制肿瘤和促进 DNA 损伤修复的作用。一旦发生突变,其 DNA 损伤修复功能受...
BRCA基因的英文全称是breast cancer susceptibility gene,也叫做乳腺癌易感基因,包括BRCA1和BRCA2,其中BRCA1基因位于第17号染色体,BRCA2基因位于第13号染色体。它们是重要的抑癌基因,其编码产物参与了DNA损伤同源性重组修复(Homologous Recombination Repair, HRR) ,担当着人体“修理工”的角色。因此,BRCA1/2 基因突变...
BRCA1和BRCA2是乳腺癌易感基因(breast cancer susceptibility gene,BRCA),是重要的抑癌基因,其编码产物参与DNA损伤同源性重组修复(homologous recombination repair)。同源重组缺陷(homologous recombination deficiency,HRD)可以由BRCA1/2基因突变导致,使得基因组不稳定...
[6] O'Donovan PJ, Livingston DM. BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis. 2010;31(6):961-967. doi:10.1093/carcin/bgq069 [7] Grinda T, Delaloge S. BRCA2: a 25-year journey from gene identific...
BRCA2 (breast cancer 2, early onset) is a protein-coding gene. Diseases associated with BRCA2 include fanconi anemia, complementation group d1, and breast-ovarian cancer, familial, 2. GO annotations related to this gene include histone acetyltransferase