This finding suggests that other genes may be the principal targets for somatic mutation in breast carcinoma. A second, recently identified familial breast cancer gene, BRCA2 (refs 5-8), accounts for a proportion of breast cancer roughly equal to BRCA1. Like BRCA1, BRCA2 behaves as a ...
In case of women with mutations in BRCA gene, one of the recommended ways to reduce the risk of breast cancer is a long breastfeeding. Taking into consideration the increasing number of patients who carry mutation in BRCA1 and were diagnosed with breast cancers during pregnancy as ...
There is evidence, although not completely consistent, that BRCA mutation carriers are more likely to develop TNBC [4, 37,38,39]. In our study we found similar absolute incidence of TNBC across all immigrant groups except for a lower incidence in women from Sub-Saharan Africa and South-East...
摘要: Increasing incidence of breast cancer in family with BRCA1 mutation. By - Steven Narod, Henry Lynch, Theresa Conway, Patrice Watson, Jean Feunteun, Gilbert Lenoir关键词: AORTIC COARCTATION AORTA, ABDOMINAL INTERMITTENT CLAUDICATION HYPERTENSION SURGERY DOI: 10.1016/0140-6736(93)92468-9 被引...
Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations The risks for cancers other than breast (BC) or ovarian (OC) cancer in breast cancer gene 1 and 2 (BRCA1/2) mutation carriers were elevated in studies of c... L Kadouri,A Hubert,Y Rotenberg,... - 《Journal of Me...
Women with a mutation in BRCA1 or BRCA2 have a high risk of developing breast cancer and of contralateral cancer after the initial diagnosis of breast canc... SA Narod,JS Brunet,P Ghadirian,... - 《Lancet》 被引量: 1200发表: 2000年 Tamoxifen and risk of contralateral breast cancer in ...
Effect of short-term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1 and BRCA2 mutation carr... Bilateral prophylactic oophorectomy (BPO) is widely used for cancer risk reduction in women with BRCA1/2 mutations. Many premenopausal women...
In contrast, a woman with an inherited mutation in the BRCA1 gene carries an elevated lifetime risk of developing breast cancer. In general, risk factors for cancer include age, sex, family medical history, exposure to cancer-causing factors in the environment, and various lifestyle choices (...
Although the proportion of high-risk women carrying this PALB2 mutation is low, research efforts should continue in order to effect its translation into clinical genetic testing practice. 展开 关键词: PALB2 Hereditary breast cancer Familial cancer centre BRCA1 and BRCA2 mutation negative ...
Porter DE, Cohen BB, Wallace MR, Smyth E, Chetty U, Dixon JM, et al.: Breast cancer incidence, penetrance and survival in prob- able carriers of BRCA1 gene mutation in families linked to BRCA1 on chromosome 17q12-21. Br J Surg 1994, 81:1512-1515....