Rates of BRCA1/2 mutation testing among young survivors of breast cancer. Breast Can- cer Res Treat 2016; 155: 165-73.Kehl, K.L.; Shen, C.; Litton, J.K.; Arun, B.; Giordano, S.H. Rates of BRCA1/2 mutation testing among young survivors of breast cancer. Breast Cancer Res. ...
Breast cancer rates and median age of onset differ between Western Europe and North Africa. In Western populations, 5 to 10 % of breast cancer cases can be attributed to major genetic factors such asBRCA1andBRCA2, while this attribution is not yet well defined among Africans. To help determi...
7.Byrski T, Huzarski T, Dent R, et al: Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Can- cer Res Treat 147:401-405, 2014 8.Byrski T, Gronwald J, Huzarski...
Objective To explore the clinical significance and expression of BRCA1 and Ki-67 protein in tissue of young patients with breast cancer.Methods 60 breast cancer patients older than 35 years old were selected as the study group,60 patients less than 35 years old as control group.Then the immuno...
7.Byrski T, Huzarski T, Dent R, et al: Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Can- cer Res Treat 147:401-405, 2014 8.Byrski T, Gronwald J, Huzarski T, et al: Path- ologic complete response rates in young women with BRCA...
A: Comparison of 5-year survival rates between HER2-negative and HER2-positive breast cancer tissues;B: Comparison of 5-year survival rates between BRCA1-negative and BRCA1-positive breast cancer patients 3 讨论 HER2是胃癌和...
Rates of 15-year breast cancer-specific survival were 86.2% with BCT, 78.7% with unilateral mastectomy, and 88.7% with bilateral mastectomy. On multivariate analysis, the hazard ratio for mortality in the group who underwent unilateral mastectomy versus BCT was 1.22 (95% CI 0.92-1.62), and was...
However, in cases associated with strong family history, mutation rates are higher, ranging from 16% to 26% for BRCA11–3 and from 7% to 13% for BRCA2.2,3 However, many breast cancer patients with strong family histories have no obvious mutations in BRCA1/2. While there is an active ...
The positive rates of BRCA1 and BRCA2 were lower in breast cancer tissues than in cancer adjacent tissues and adenosis tissues,with a significant difference(P<0.05). The gene BRCA1/BRCA2 was negatively correlated with lymph node metastasis, and negatively correlated with the expression of ...
Breast cancer is the most common malignancy that develops in women worldwide, its incidence continues to rise and itis responsible for the highest death rates. Breast cancer can be classified as sporadic or familial – the strongest riskfactor today is a family history. Germline mutations in high...