JAMA:检测出BRCA1/2基因突变,应该切除乳房吗? 谈起BRCA1和BRCA2基因(Breast Cancer Susceptibility)相信大家都有所了解,这是早在20世纪初就被证实直接与遗传性乳腺癌有关的基因,拥有该突变的人群患乳腺癌的概率更高。 后续,让这两个基因与乳腺癌的关联更为人所知的,应该是好莱坞红星安吉丽娜﹒朱莉,她因为家族乳腺...
[2]Kuchenbaecker KB, Hopper JL, Barnes DR, et al. Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers. JAMA. 2017;317(23):2402-2416. doi:10.1001/jama.2017.7112 [3]Oh M, Alkhushaym N, Fallatah S, et al. The association of BRCA1 and BRCA...
Ping Liu,Chao Wu,Shengli Yang,Department of Surgery,Liyuan Hospital,Tongji Medical College,Huazhong University of Science and Technology,,.Research progress on the relationship between BRCA1 and hereditary breast cancer.[J];中德临床肿瘤学杂志(英文版),2013-12Research progress on the relationship ...
作者表示,他们研究的结果对临床也具有指导意义。例如,BIC(The Breast Cancer Information Core)数据库中对BRCA1基因上的很多变异的解释是互相矛盾的,而本实验得到的结果可能可以更新现有的数据库。 当然,研究人员表示这次只评估了BRCA1基因重要位点的变异,接下来两年,他们要将评估范围扩大到整个基因。届时,我们对该基因...
BRCA,英语是BReastCAncer gene,直译是“乳腺癌基因”,一般称“乳腺癌易感基因”,来源于英语Breast cancer susceptibility genes。 BR是Breast的前两个字母,CA是Cancer的前两个字母。 BRCA1英语是BReast CAncer gene 1 , BRCA2 英语...
[6]. Lønning PE, Nikolaienko O, Pan K, et al. Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer [published online ahead of print, 2022 Sep 8]. JAMA Oncol. 2022;e223846. doi:10.1001/jamaoncol.2022.3846 ...
作者表示,他们研究的结果对临床也具有指导意义。例如,BIC(The Breast Cancer Information Core)数据库中对BRCA1基因上的很多变异的解释是互相矛盾的,而本实验得到的结果可能可以更新现有的数据库。 当然,研究人员表示这次只评估了BRCA1基因重要位点的变异,接下来两年,他们要将评估范围扩大到整个基因。届时,我们对该基因...
More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women. According to aJAMA Oncologyreview articleby experts at Fred Hutch Cancer Center and University of Washington, newly developed ...
Breast cancers arising in germline carriers of BRCA1 mutations have a characteristic phenotype that has been shown in many studies to differentiate BRCA1 tumours from sporadic tumours. Recently, it has become clear that the characteristic phenotype of BR
[6]. Lønning PE, Nikolaienko O, Pan K, et al. Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer [published online ahead of print, 2022 Sep 8]. JAMA Oncol. 2022;e223846. doi:10.1001/jamaoncol.2022.3846...