Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer. 2007; 7 :937–948. doi: 10.1038/nrc2054. [ Cross Ref ]Fackenthal JD, Olopade OI: Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer 2007, 7: 937–948....
Mutations in BRCA1 predispose to breast cancer. CTIP interacts with BRCA1 and so could also be associated with increased risk. We screened CTIP for germlin
乳腺癌的危险因素(Risk factors) 年龄增大(older age) 丰满的乳房(dense breast) 之前发生过乳腺癌 父母或兄弟姐妹,有乳腺癌发生 遗传性基因突变(BRCA1 & BRCA2基因突变) 拥有德系犹太人的祖先 饮酒(大量) 体重超重或者肥胖,尤其...
Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers PURPOSE: The objective of this study was to estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers; and measure the extent to which h... K Metcalfe,S Gershman,HT Lynch,... - 《Br J Canc...
mutationshad of developing cancer in both breasts, known as contralateral breast cancer. For example, they found that carriers of ATM mutations did not have a significantly elevated risk of contralateral breast cancer, whereas those with BRCA1, BRCA2 and CHEK2 mutations had double the risk....
Variation of breast cancer risk among BRCA1/2 carriers. JAMA. 2008;299(2):194-201.ArticlePubMedGoogle ScholarCrossref 5. Brohet RM, Velthuizen ME, Hogervorst FB, et al; HEBON Resource. Breast and ovarian cancer risks in a large series of clinically ascertained families with a high ...
“We are now testing people not just for the BRCA mutations, but for mutations in these other genes that can increase the risk of cancer and breast cancer,” she told TODAY. 5. If you test negative, it doesn’t mean you’re in the clear. ...
alteration in the BRCA1 gene have about a 72% chance of developing breast cancer by age 80, and those with an inherited alteration in the BRCA2 gene have about a 69% chance of developing breast cancer. There are several other types of abnormal genes that increase risk of breast cancer. ...
The precise manner in which physical changes to the breast cancer susceptibility protein (BRCA1) affect its role in DNA repair events remain unclear. Indeed, cancer cells harboring mutations in BRCA1 suffer from genomic instability and increased DNA lesions. Here, we used a combination of molecular...
mutationshad of developing cancer in both breasts, known as contralateral breast cancer. For example, they found that carriers of ATM mutations did not have a significantly elevated risk of contralateral breast cancer, whereas those with BRCA1, BRCA2 and CHEK2 mutations had double the risk....