[3]Oh M, Alkhushaym N, Fallatah S, et al. The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta-analysis. Prostate. 2019;79(8):880-895. doi:10.1002/pros.23795 [4]Hu C, Hart SN, Polley EC, et al. Association Between Inherited Ge...
这些结果表明了BRCA1-BARD1-RAD51复合体在通过同源重复修复DNA损伤方面的中心作用。 “确定基于BRCA的DNA修复通路的具体机制将帮助科学家们设计出更为有效地杀灭癌细胞的药物,”Sung 博士说:“而且了解这一机制将给予医生们预测患者癌症风险的能力。” 参...
[1] Yukihide Momozawa, et al.,(2022). Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants. JAMA Oncol, DOI: 10.1001/jamaoncol.2022.0476. [2] Q&A: Genetic abnormalities and cancer risk. Retrieved Aug 15 ,2022,from ...
[1]Momozawa Y,et al.Expansion of Cancer Risk Profile for BRCA1 and BRCA2 Pathogenic Variants.JAMA Oncol.2022 Jun 1;8(6):871-878.doi:10.1001/jamaoncol.2022.0476.PMID:35420638;PMCID:PMC9011177.[2]https://www.medscape.com/viewarticle/976993?src= [3]Win,Aung Ko,et al.Cancer Epidemio...
Suggests that BRCAI carriers, in addition to very high risks of breast and ovarian cancer, also suffer substantially increased risks of colon and prostate cancer. Maximum likelihood estimate of the relative risk of colon cancer in carriers compared with the general population; Maximum likelihood ...
[3]Oh M, Alkhushaym N, Fallatah S, et al. The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta-analysis. Prostate. 2019;79(8):880-895. doi:10.1002/pros.23795 [4]Hu C, Hart SN, Polley EC, et al. Association Between Inherited Ge...
[3]. Lønning PE, Berge EO, Bjørnslett M, et al. White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk. Ann Intern Med. 2018;168(5):326-334. doi:10.7326/M17-0101 [4]. Lønning PE, Eikesdal HP, Løes IM, Knappskog S. Constitutional Mosaic Epimutations ...
BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified,...
1. Sun J, Chu F, Pan J, et al. BRCA-CRisk: A Contralateral Breast Cancer Risk Prediction Model for BRCA Carriers[J]. Journal of Clinical Oncology, 2023: JCO. 22.00833. 2. Robson M, Im SA, Senkus E, et al.Olaparibfor metastatic breast cancer in patients with a germline BRCA mutatio...
本研究采用回顾性队列分析对来自21个国家或中心的5707名BRCA1和3535名BRCA2携带者的前瞻性随访研究数据进行跟踪研究。 了解华大基因产前诊断,胚胎植入前诊断多种产品信息>>> 原文检索:The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations ...