Suggests that BRCAI carriers, in addition to very high risks of breast and ovarian cancer, also suffer substantially increased risks of colon and prostate cancer. Maximum likelihood estimate of the relative risk of colon cancer in carriers compared with the general population; Maximum likelihood ...
[4]Hu C, Hart SN, Polley EC, et al. Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. JAMA. 2018;319(23):2401-2409. doi:10.1001/jama.2018.6228 [5]Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl C...
[4]Hu C, Hart SN, Polley EC, et al. Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. JAMA. 2018;319(23):2401-2409. doi:10.1001/jama.2018.6228 [5]Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl C...
Cancer risks among BRCA1 and BRCA2 mutation carriers 来自 Semantic Scholar 喜欢 0 阅读量: 104 作者:E Levy-Lahad,E Friedman 摘要: BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying ...
[5]. Hitchins MP. Constitutional epimutation as a mechanism for cancer causality and heritability?. Nat Rev Cancer. 2015;15(10):625-634. doi:10.1038/nrc4001 [6]. Lønning PE, Nikolaienko O, Pan K, et al. Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Canc...
Risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: impact of adjuvant systemic treatment de los Rios P, Weber B, Lynch H (2000) Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case - control st... Collee,M.,Hooning,......
Objective: Female carriers of BRCA1/BRCA2 mutations (BRCAm) are at increased risk of developing breast and ovarian cancer. The main prevention options currently available consist in either clinical-radiological surveillance or risk-reducing surgery. This study investigated factors which might influence ...
一般人群中,复方口服避孕药(combined-type oral contraceptive preparations,COCP)的使用大大降低了女性罹患卵巢癌和子宫内膜癌的风险(relative risk,RR=0.50),但轻度增加了乳腺癌的风险(RR=1.17-1.27)。随着COCP使用时间的延长对罹患相关肿瘤的相对风险也...
this observation offers opportunities for more efficient and less costly BRCA1/2 cancer screening. The study also suggests that previously reported risk towards prematurely diminished ovarian reserve in association with BRCA mutations is FMR1-mediated, and offers a possible explanation for the so-called...
Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers PURPOSE: The objective of this study was to estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers; and measure the extent to which h... K Metcalfe,S Gershman,HT Lynch,... - 《Br J Canc...