如果能够在突变携带者患病之前通过BRCA1/2基因检测筛选出突变携带者，则可以通过药物，增加筛查或手术等方式来预防数百万癌症的发生。2020年7月，英国玛丽皇后大学的科研人员在" Cancers"杂志上在线发表了题为"Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health ...
2020年7月17日,发表在《Cancers》上的一项国际研究显示:与目前的临床实践相比,对整个人群进行乳腺癌和卵巢癌易感基因BRCA1/2突变筛查可以预防全球范围内数以百万计的乳腺癌和卵巢癌发生。 研究人员模拟了基于人群的BRCA1/2检测模型(马尔可夫模型),对美国、英国、荷兰、中国、巴西和印度6个不同收入国家,年龄≥30岁...
如果能够在突变携带者患病之前通过BRCA1/2基因检测筛选出突变携带者,则可以通过药物,增加筛查或手术等方式来预防数百万癌症的发生。 2020年7月,英国玛丽皇后大学的科研人员在"Cancers"杂志上在线发表了题为"Economic Evaluation of Population-Based BRCA1/BRCA2 Mutation Testing across Multiple Countries and Health Sy...
RESULTS: Over a mean follow-up of 5.6 years, 350 new breast cancers were diagnosed. Among women with a BRCA1 or BRCA2 mutation, oophorectomy was not associated with breast cancer risk compared with women who did not undergo an oo...
对所有女性进行BRCA1/2基因突变检测是一种更具成本效益的策略。 参考资料: 1.Manchanda Ranjit,Sun Li,Patel Shreeya et al. BRCA1/BRCA2Economic Evaluation of Population-Based Mutation Testing across Multiple Countries and Health Systems.[J] .Cancers (Basel), 2020, 12: undefined....
2020年7月17日,发表在《Cancers》上的一项国际研究显示:与目前的临床实践相比,对整个人群进行乳腺癌和卵巢癌易感基因BRCA1/2突变筛查可以预防全球范围内数以百万计的乳腺癌和卵巢癌发生。 研究人员模拟了基于人群的BRCA1/2检测模型(马尔可夫模型),对美国、英国、荷兰、中国、巴西和印度6个不同收入国家,年龄≥30岁...
Surprisingly, mutations in BRCA2 are infrequent in cancers including breast carcinoma. However, a probable germline mutation in a pancreatic tumour cell line suggests a role for BRCA2 in susceptibility to pancreatic cancer.doi:10.1038/ng0696-241Teng, David H.-R...
[4]Lang G T, Shi J X, Hu X, et al. The spectrum of BRCA mutations and characteristics of BRCA‐associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next‐generation sequencing[J]...
[4]Lang G T, Shi J X, Hu X, et al. The spectrum of BRCA mutations and characteristics of BRCA‐associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next‐generation sequencing[J]. International Journal of Cancer, 2017, 141(1): 129-142. ...
Seven of the nine disease-associated mutations were detected in the 50 men with breast cancers; thus in our series, BRCA2 mutations account for 14% of male breast cancer, all but one of which had a family history of male and/or female breast cancer. This is a preview of subscription ...