Role of BRCA1 and BRCA2 mutations in pancreatic cancer. Gut, Vol. 56, No.5, (May 2007), pp.601-605, ISSN 0017-5749.Greer JB, Whitcomb DC (2007) Role of BRCA1 and BRCA2 mutations in pancreatic cancer. Gut 56(5):601–605. : 10.1136/gut.2006.101220...
mutations inBRCA2are associated with superior response compared to those inBRCA1. Mutations inBRCA1andBRCA2result in distinct mutational landscapes and differentially modulate the tumor-immune microenvironment, with gene expression programs related to both adaptive and innate immunity enriched inBRCA2-...
In French-Canadian women, BRCA2 mutations outnumber BRCA1 mutations by a ratio of approxi- mately 3:1; there is also a preponderance of BRCA2 over BRCA1 in Iceland (10) and in China (11), but in Poland (7) and the Bahamas (9), BRCA1 mutations predominate. The mutation yield of ...
BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified,...
The risk of developing cancer is not identical for all carriers of BRCA1 and BRCA2 mutations. Risk can be influenced by allelic heterogeneity, modifier genes, and environmental and hormonal cofactors. Abstract The discovery of the first gene associated with hereditary breast cancer, BRCA1, was ant...
Hampel H. Recontacting patients who have tested negative for BRCA1 and BRCA2 mutations: how, who and why? J Genet Couns 2009;18(6):527-529.Hampel, H. (2009). Recontacting patients who have tested negative for BRCA1 and BRCA2 mutations: how, who and why? J Genet Counsel, 18, 527...
Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with many cases of early-onset breast cancer. However, in an outbred population, the prevalence of BRCA1 and BRCA2 mutations in patients with breast cancer who were unselected ...
Three founder mutations in the cancer-associated genes BRCA1 and BRCA2 occur frequently enough among Ashkenazi Jews to warrant consideration of genetic testing outside the setting of high-risk families with multiple cases of breast or ovarian cancer. We estimated the prevalence of these founder mutat...
Members of families with BRCA1 mutations had a 1.6-fold (95% CI, 1.2-fold to 2.3-fold) higher risk of contralateral breast cancer than members of families with BRCA2 mutations. Younger age at first breast cancer was associated with a significantly higher risk of contralateral breast cancer in...
Germline BRCA1 and BRCA2 mutations in Brazilian ovarian and breast cancer patients [abstract]. In: Proceedings of the AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; So Paulo, Brazil. ...