BRCA1 mutations increase risk of prostate cancerdoi:10.1016/S1470-2045(12)70182-1Neil BennetThe Lancet Oncology
如果三阴性乳腺癌(TNBC)幸存者中子宫浆液性癌的额外风险是由于两组人群之间BRCA1致病突变率差异所导致,我们将估算这种差异下BRCA1突变与USC之间的关联度。 Methods Using the Surveillance, Epidemiology, and End Results 17 registry dat...
In hopes that won't happen, many women are choosing to be tested for what's been called the “breast cancer gene” — BRCA. Mutations of the BRCA1 and BRCA2 genes can significantly increase the risk of developing cancer. Related The statistics are eye-opening: 12.8% of women in the U....
Variation of breast cancer risk among BRCA1/2 carriers. JAMA. 2008;299(2):194-201.ArticlePubMedGoogle ScholarCrossref 5. Brohet RM, Velthuizen ME, Hogervorst FB, et al; HEBON Resource. Breast and ovarian cancer risks in a large series of clinically ascertained families with a high ...
In addition to BRCA1 and BRCA2, other genes involved in DNA repair by homologous recombination harbor mutations that increase risk of breast and ovarian cancer. For some of these genes, such as PALB2, the spectrum and risks associated with loss-of-function mutations are well characterized.8 ...
BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) encode for tumor suppressor proteins which are critical regulators of the Homologous Recombination (HR) pathway, the most precise and important DNA damage response mechanism. Dysfunctional HR
BRCA1 and BRCA2 pathogenic variants (PVs) are associated with prostate cancer (PCa) risk, but a wide range of relative risks (RRs) has been reported. We systematically searched PubMed, Embase, MEDLINE and Cochrane Library in June 2021 for studies that es
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BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) encode for tumor suppressor proteins which are critical regulators of the Homologous Recombination (HR) pathway, the most precise and important DNA damage response mechanism. Dysfunctional HR
developing breast cancer or may be at increased risk of developing prostate cancer. The test only detects three out of more than 1,000 known BRCA mutations. This means a negative result does not rule out the possibility that an individual carries other BRCA mutations that increase cancer risk....