参考资料 [1] Chunling Hu, et al., (2021). population-based study of genes previously implicated in breast cancer. N Engl M Med,DOI: 10.1056/nejmoa2005936. [2] Breast cancer risk genes. (2021). Breast Cancer Association Consortium "Breast cancer risk genes -- association analysis in more...
Definition Mutations in the breast cancer genes BRCA1 and BRCA2 cause elevated risks to breast and ovarian cancer. BRCA1 maps to chromosome 17 (band q21), BRCA2 maps to chromosome 13 (band q12). At the genetic level there are interesting analogies between the two genes, even though they ...
[1] Mystery of breast cancer risk gene solved, 20 years after its discovery [2] BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing
[4]Hu C, Hart SN, Polley EC, et al. Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. JAMA. 2018;319(23):2401-2409. doi:10.1001/jama.2018.6228 [5]Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl C...
[4]Hu C, Hart SN, Polley EC, et al. Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer. JAMA. 2018;319(23):2401-2409. doi:10.1001/jama.2018.6228 [5]Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. J Natl ...
[2] Yao L, Sun J, Zhang J, et al. Breast cancer risk in Chinese women with BRCA1 or BRCA2 mutations[J]. Breast Cancer Res Treat, 2016,156(3):441-445. [3] Hoppe MM, Sundar R, Tan DSP, et al. Biomarkers for...
[3]Breast Cancer Association Consortium. Dorling L, Carvalho S, Allen J, González-Neira A, et al. Breast cancer risk genes—association analysis in more than 113,000 women. N Engl J Med. 2021 doi: 10.1056/NEJMoa1913948. [4]McCart Reed AE, Kalaw E, Nones K, Bettington M, Lim M,...
了解华大基因产前诊断,胚胎植入前诊断多种产品信息>>> 原文检索:The Influence of Number and Timing of Pregnancies on Breast Cancer Risk for Women With BRCA1 or BRCA2 Mutations (生物通:伍松)
谈起BRCA1和BRCA2基因(Breast Cancer Susceptibility)相信大家都有所了解,这是早在20世纪初就被证实直接与遗传性乳腺癌有关的基因,拥有该突变的人群患乳腺癌的概率更高。 后续,让这两个基因与乳腺癌的关联更为人所知的,应该是好莱坞红星安吉丽娜﹒朱莉,她因为家族乳腺癌病史、自身BRCA1基因突变,接受了预防性的双侧...
[6]. Lønning PE, Nikolaienko O, Pan K, et al. Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer [published online ahead of print, 2022 Sep 8]. JAMA Oncol. 2022;e223846. doi:10.1001/jamaoncol.2022.3846...