For example, recent health economic studies of genetic testing for an increased risk of breast cancer suggest that it is associated with higher cost-effectiveness to screen for pathogenic variants in a seven gene panel rather than the usual two gene test for variants in BRCA1 and BRCA2. ...
BRCA是Breast Cancer Susceptibility Gene,翻译成中文就是指乳腺癌易感基因。 BRCA包括BRCA1和BRCA2,是人体内重要的抑癌基因,其编码的产物参与DNA损伤同源性重组修复。 DNA损伤修复示意图 艾宝顿医生,您看我得的是卵巢癌,怎么却是乳腺癌相关易感基因...
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a ...
乳腺癌易感基因(breast cancer susceptibility gene, BRCA)与乳腺癌有着密不可分的关系。BRCA基因的两个成员,即BRCA1和2,分别是在1990年和1994年被分离。 乳腺癌可以分为遗传性乳腺癌和散发性乳腺癌(sporadic breast cancer),散发性乳腺癌指的是没有发现明确的遗传基因改变(完整的癌变点)与乳腺癌家族史的乳腺癌。
Objective: The presence of BRCA gene mutation and J Huszno,M Budryk,Z Koosza,... 被引量: 0发表: 0年 Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood. Osteosarcoma is the most frequent second primary cancer occurring during the first 20 years following...
[Abstract]Germline mutations in BRCA genes (including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a family history of cancer, can play a preventive role by reducing ...
We assessed the PREDICT v 2.2 for prognosis of breast cancer patients with pathogenic germline BRCA1 and BRCA2 variants, using follow-up data from 5453 BRCA1/2 carriers from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast C
Loss-of-function variants in the BRCA1 and BRCA2 susceptibility genes predispose carriers to breast and/or ovarian cancer. The use of germline testing panels containing these genes has grown dramatically, but the interpretation of the results has been co
2 germline mutations who receive radiotherapy after surgery may not increase the risk of developing a second primary tumor. [Key words]Breast cancer;BRCA1;BRCA2; Radiotherapy; Second primary cancer 乳腺癌如今已超越肺癌成为全球发...
(2014). Accuracy of recall of information about a cancer predisposing BRCA1/2 gene mutation amongst patients and relatives. European Journal of Human Genetics. doi:10.1038/ejhg.2014.84.Jacobs, C., Dancyger, C., Smith, J. A., Michie, S. (2014). Accuracy of recall of information about a...