^Paul A, Paul S. The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Front Biosci (Landmark Ed). 2014 Jan 1;19(4):605-18. ^Wright WD, Shah SS, Heyer WD. Homologous recombination and the repair of DNA double-strand breaks. J Biol Chem. 2018 Jul 6;293(27...
Breast Cancer Susceptibility Gene1 (BRCA1) is a tumor suppressor gene for breast and ovarian cancers. The gene locates at chromosome 17q21 and encodes for 1863 amino acids protein. It is believed that BRCA1 protein is involved in many functions such as DNA repair, centrosome replication, cell...
6. Aleskandarany M, Caracappa D, Nolan CC, et al. DNA damage response markers are differentially expressed in BRCA-mutated breast cancers. Breast Cancer Res Treat. 2015;150(1):81-90. doi:10.1007/s10549-015-3306-6 7. ZHONG Q, PENG H ...
BRCA1/BRCA2 基因检测 新基因格医学 重大疾病检验 BRCA(BReast CAncer susceptibility gene;乳腺癌易感基因)是重要的抑癌基因与肿瘤易感基因,包括BRCA1及BRCA2。BRCA基因突变会导致基因组不稳定性显著增加,从而显著提高女性罹患乳腺癌、卵巢癌以及其他癌症(如:胰腺癌、子宫内膜癌、腹膜癌及宫颈癌等[1-4])的风险。
To test the idea, Park’s team first selected cell lines derived from non-cancerous human breast epithelial cells – where BRCA1 breast cancers originate. They then used an advanced gene-targeting technique to create new cell lines that have a typical cancer-linked BRCA1 mutation in only one...
BRCA1/BRCA2 基因检测 新基因格医学 重大疾病检验 BRCA(BReast CAncer susceptibility gene;乳腺癌易感基因)是重要的抑癌基因与肿瘤易感基因,包括BRCA1及BRCA2。BRCA基因突变会导致基因组不稳定性显著增加,从而显著提高女性罹患乳腺癌、卵巢癌以及其他癌症(如:胰腺癌、子宫内膜癌、腹膜癌及宫颈癌等[1-4])的风险。
乳癌易感性基因-Brca1的作用机制 BRCA1 is a gene that normally acts to restrain the growth of cells. It suppresses the formation of tumors. Or in the terminology of cancer genetics, BRCA1 is a tumor suppressor. (The symbol BRCA comes from the first two letters of "BReast" and "CAncer"....
Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript ...
Mutation analysis of Breast cancer gene 1 (BRCA1) in primary ovarian cancers DENG Wen-guo,ZENG Rui-ping,JIANG Wei-ying,et al. Department of Medical Genetics, Sun Yat-sen University of Medical Sciences,Guangzhou 510089,P.R. China 【Abstract】Objective: To analyze the role and types of breast...
Mutations of the human BRCA1 and BRCA2 genes encoding tumor suppressors have been implicated in inherited predisposition to breast and other cancers. Disruption of the homologous mouse genes Brca1 and Brca2 by targeting showed that they ... T Ludwig,DL Chapman,VE Papaioannou,... - 《Genes &...