The function of their large, nuclear-localised protein products remains uncertain, but they have been implicated in the cellular response to DNA damage and in the regulation of gene transcription. BRCA1 and BRCA2 are highly distinct genes, despite the similarity in their acronyms. Characteristics ...
探秘BRCA1/2 甲基化密码:解锁遗传性乳腺癌和卵巢癌诊疗新方向 《Clinical and Translational Oncology》:BRCA1/2 methylation and expression dynamics in hereditary breast and ovarian cancer: insights from gene, protein, and TCGA analysis 编辑推荐: 为探究 BRCA1/2 启动子甲基化对遗传性乳腺癌和卵巢癌的影响...
The discovery of the BRCA1 gene had an immediate and profound impact on medical practice by providing a means to assess and manage breast and ovarian cancer risk in individuals and their families carrying a mutation in the gene. The patenting of BRCA1 and then BRCA2 (another cancer-...
Inherited inactivating mutations inBRCA1 or BRCA2seem to cause a similar predisposition to breast and ovarian cancer, but a closer look reveals many differences as well. This Perspective discusses the similarities and differences between BRCA1 and BRCA2
inBRCA2are associated with superior response compared to those inBRCA1. Mutations inBRCA1andBRCA2result in distinct mutational landscapes and differentially modulate the tumor-immune microenvironment, with gene expression programs related to both adaptive and innate immunity enriched inBRCA2-deficient ...
Annual screening strategies in BRCA1 and BRCA2 gene mutation carriers: A comparative effectiveness analysis. Cancer 2012; 118: 2021-30.Lowry KP, Lee JM, Kong CY, et al. Annual screening strategies in BRCA1 and BRCA2 gene mutation carriers: a comparative effec- tiveness analysis. Cancer (...
gene signature, which they thought was predictive. That obviously needs to be validated in another setting, and whether that translates into anything meaningful in the clinical setting is not clear because other attempts to look at this, like Andy Tutt’s TNT study, were kind of disappointing....
Mutations of the BRCA-1 and BRCA-2 gene and possibilities for predictive testing. Mol Med Today 1997;3:168-174.Gayther SA, Ponder BA (1997) Mutations of the BRCA1 and BRCA2 genes and the possibilities for predictive testing. Mol Med Today 3 : 168-174....
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. ... K Yoshida,Y Miki - ...
Statistical analyses were performed for time-to-event end points (iDFS, distant disease-free survival [DDFS], and overall survival [OS]).#Of the 442 patients, 42 carried PVs in any cancer predisposition gene; 15 carriedBRCA1/2PVs. Irrespective of the treatment arms, PV status was not a ...