The function of their large, nuclear-localised protein products remains uncertain, but they have been implicated in the cellular response to DNA damage and in the regulation of gene transcription. BRCA1 and BRCA2 are highly distinct genes, despite the similarity in their acronyms. Characteristics ...
The proteins encoded by the two major breast cancer susceptibility genes,BRCA1andBRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair. BRCA1 is a pleiotropic DDR protein that functions in...
The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about ...
The Role of the BRCA1 Tumor Suppressor in DNA Double-Strand Break Repair The tumor suppressor gene BRCA1 was cloned in 1994 based on its linkage to early-onset breast and ovarian cancer. Although the BRCA1 protein has been impli... Zhang,J - 《Molecular Cancer Research》 被引量: 334发表...
Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection. Conclusions While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure...
Prevalence of BRCA1 and BRCA2 gene mutations in families with medium and high risk of breast and ovarian cancer in Brazil Of all malignant neoplasias affecting women, breast cancer has the highest incidence rate in Brazil. The objective of the present study was to determine th... VF Esteves...
In recent years, numerous studies have assessed the prevalence of germline mutations in BRCA1 and BRCA2 genes in various cohorts. We here extensively investigated the prevalence and geographical distribution of BRCA1-2 mutations in the entire genetically
doi:info:doi/10.1111/j.1445-2197.2007.04114_19.xFirgaira, F.ANZ Journal of Surgery
The probability of being a BRCA1 and/or BRCA2 gene carrier was calculated for each woman. Among predicted noncarriers, logistic regression was used to assess the relationship (odds ratios and 95% confidence intervals [CIs]) between case or control status and family history of breast or ovarian...
摘要: The article announces that Doctor Mary-Claire King has been presented with the 2014 Lasker-Koshland Special Achievement Award in Medical Science for her discovery of a single gene BRCA1 that causes a form of hereditary breast cancer.关键词:...