The function of their large, nuclear-localised protein products remains uncertain, but they have been implicated in the cellular response to DNA damage and in the regulation of gene transcription. BRCA1 and BRCA2 are highly distinct genes, despite the similarity in their acronyms. Characteristics ...
The proteins encoded by the two major breast cancer susceptibility genes,BRCA1andBRCA2, work in a common pathway of genome protection. However, the two proteins work at different stages in the DNA damage response (DDR) and in DNA repair. BRCA1 is a pleiotropic DDR protein that functions in...
The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about ...
To the Editor: A family history of breast and/or ovarian cancer is associated with an increased chance of carrying a mutation in the BRCA1 or BRCA2 gene. N... R Kaldate,A Huston,H Mccoy,... - 《Breast Journal》 被引量: 0发表: 2014年 Molecular characterization of BRCA1 and BRCA2 ...
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. ... K Yoshida,Y Miki - ...
Finally, we also sequenced and analyzed BRCA2 from 24 primate species and find that this gene has also evolved under positive selection. Conclusions While mutations leading to truncated forms of BRCA1 are clearly linked to cancer phenotypes in humans, there is also an underlying selective pressure...
2 cases of OC in which a germline heterozygous pathogenic variant in the ATM gene was identified: the first in the contest of Hereditary Breast and Ovarian Cancer (HBOC) family history and, in the other one, a late onset of neoplasms, to underline the importance of defining guidelines and ...
inBRCA2are associated with superior response compared to those inBRCA1. Mutations inBRCA1andBRCA2result in distinct mutational landscapes and differentially modulate the tumor-immune microenvironment, with gene expression programs related to both adaptive and innate immunity enriched inBRCA2-deficient ...
At the same time in 1994, the BRCA2 gene was discovered by Stratton and Wooster at The Institute of Cancer Research, UK. The identification of BRCA1 and BRCA2 were significant milestones in the management of families with breast and ovarian cancers, facilitating the subsequent incorporation of ...
摘要: The article announces that Doctor Mary-Claire King has been presented with the 2014 Lasker-Koshland Special Achievement Award in Medical Science for her discovery of a single gene BRCA1 that causes a form of hereditary breast cancer.关键词:...