Experiences of BRCA1/2 Gene Mutation-Positive Women With Cancer in Communicating Genetic Risk to Their RelativesBRCACancerExperiencesFamilyGeneticRisk communicationBackgroundSeven, MemnunShah, Lisa L.Daack-Hirsch, SandraYazici, HulyaUniv Massachusetts Coll Nursing 230 Skinner Hall 651 N Pleasant St ...
针对其开展分析,分别在非BRCA1/2胚系突变患者(n=261)与BRCA1/2胚系突变患者(n=31)中进行多元logistic回归分析,以评估影响第二原发肿瘤的风险因素,并对上述两人群中的分析结果进行交互作用分析,从而评估BRCA1/2胚系突变与放疗的交互作用。
[Abstract]Germline mutations inBRCAgenes (includingBRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population basedBRCAgene screening, particularly in high-risk individuals with a family history...
Contralateral breast cancer risk depends on age at first breast cancer and on the affected BRCA gene, and this risk should be considered in treatment planning. 展开 关键词: Humans Breast Neoplasms Neoplasms, Second Primary BRCA2 Protein Treatment Outcome Proportional Hazards Models Risk Assessment ...
2. It also allowed my MOM to knowshe has the BRCA1 gene mutation, and though she’d already had breast cancer and a double mastectomy, too, she was able to have her ovaries removed to prevent ovarian cancer, as well. 3. It also empowered my SIBLINGS, ...
BACKGROUND Poly(ADP-ribose)polymerase inhibitors(PARPis)are approved as first-line therapies for breast cancer gene(BRCA)-positive,human epidermal growth f... N Syed,AV Chintakuntlawar,D Vilasini,... - 《World Journal of Clinical Oncology》 被引量: 0发表: 2024年 A Pilot Study onBRCA1/2...
[关键词]专家共识;BRCA1;BRCA2;同源重组;突变筛查;二代测序;胚系突变 [Abstract]Germline mutations in BRCA genes (including BRCA1/2) are the major risk factors for hereditary tumors including breast and ovarian cancer. Population based BRCA gene screening, particularly in high-risk individuals with a...
BRCA1andBRCA2are tumor suppressor genes that are involved in cell growth inhibition, apoptosis, regulation of gene transcription and DNA damage repair through homologous recombination.1Thus, germ line mutations inBRCAgenes are considered to be associated with cancer susceptibility, especially with an inc...
Our study suggested that the spectrum and characteristics of BRCA1/2 mutations in Chinese fa... J Zhang,R Pei,Z Pang,... - 《Breast Cancer Research & Treatment》 被引量: 120发表: 2012年 Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations,...
The discovery of the first gene associated with hereditary breast cancer, BRCA1, was anticipated to greatly increase our understanding of both hereditary and sporadic forms of breast cancer, and to lead to therapeutic and preventive breakthroughs. Much has been learned during the past decade about ...