84 Physiological bone remodeling is delicately regulated by a complex system involving multiple cells.85 Dysfunctional remodeling results in bone fragility, such as osteoporosis.86 Osteoclasts are drawn to sites of microdamage to replace old bone with new bone, and osteoclasts are known as bone-...
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology: implication for Coffin-Lowry syndrome. Cell 117, 387–398 (2004). CAS PubMed Google Scholar Jing, D. et al. The role of microRNAs in bone remodeling. Int. J. Oral. Sci. 7, 131–143 (2015). CAS PubMed...
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direc...
Bone remodeling is a tightly regulated process securing repair of microdamage (targeted remodeling) and replacement of old bone with new bone through seque... Erik,Fink,Eriksen - 《Reviews in Endocrine & Metabolic Disorders》 被引量: 346发表: 2010年 RANKL and OPG expression by human microvascular...
cytokinesosteoblastsosteoclastsBone remodeling is a tightly regulated process securing repair of microdamage (targeted remodeling) and replacement of old bone ... EF Eriksen - 《Reviews in Endocrine & Metabolic Disorders》 被引量: 274发表: 2010年 Osteoimmunology: the expanding role of immunoreceptors ...
This inflammation and bone remodeling are critically regulated by the transcription factor NF‐κB. We previously demonstrated that inhibition of NF‐κB signaling by using the decoy oligodeoxynucleotide (ODN) mitigates polyethylene wear particle‐induced bone loss using in vitro and in vivo models. ...
TEPs containing stem cells or osteoprogenitor cells should mainly regulate regeneration and bone remodeling process by providing sufficient amount of cytokines/growth factors released by viable cells [40]. Differentiation of incorporated within the scaffold stem cells towards mature bone cells is the ...
However, when the balance is broken, that is, the function of osteoclasts is stronger than that of osteoblasts or the activity of osteoblasts is higher than osteoclasts, diseases such as osteoporosis and osteosclerosis may occur [88,89]. Moreover, in the process of bone remodeling, in ...
Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that microRNAs (miRNAs), known as a family of short non-co...
Bone: Regulating bone remodeling.The article presents information on a study which shows that the functioning of osteoclast is regulated by the adenosine diphosphate (ADP) receptor P2RY12, and the receptor also aid in therapeutic targeting for bone remodeling.doi:10.1038/nm.3003Meera Swami...