Melanoma antigen family D1 (MAGED1), an important adaptor protein, has been shown to ubiquitously express and play critical roles in many aspects of cellular events and physiological functions. However, its role in bone remodeling remains unknown. We, therefore, analyzed the bone phenotype ofMaged...
- 《Journal of Bone & Mineral Research》 被引量: 67发表: 2007年 TREM-1, a negative regulator of human osteoclastogenesis negative regulator of human osteoclast differentiation and identify a novel mechanism of negative regulation of osteoclastogenesis that plays a role in ... B Lee,JH Kim,JH ...
Osteoblasts have been identified as an essential factor in regulation of the bone remodeling process, which produce bone matrix and differentiate into osteocytes for bone formation, as well as regulate differentiation and activation of osteoclasts for bone resorption.2 The Wnt/β-catenin pathway is ...
3. Negative regulation of TLR signaling 3.1. Negative regulation of TLR signaling pathways by degradation In general, degradation or destabilization of signal transduction factors is one of the principal mechanisms that reduces or terminates the activation of signaling pathways. This type of mechanism oc...
Given that FGF is known to promote ERK1/2 signaling in the lens (74) and has also been shown to exacerbate TGFβ-induced cataracts in vitro (90), one could speculate that nega- tive regulation of FGF signaling by Spry in lens cells may suppress anterior sub- capsular cataract formation....
1 The resorption of old bone and the formation of new bone must be in balance to maintain homeostasis and a constant mass of bone. Osteoblasts have been identified as an essential factor in regulation of the bone remodeling process, which produce bone matrix and differentiate into osteocytes ...
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal neg
E26 transformation-specific transcription factor (ELK3) is highly expressed in TNBCs, and functions as a regulator of epithelial-mesenchymal transition and immune responses. Because metastatic migration and immune evasion by TNBC cells are critical factors for successful metastasis, unravelling the ...
Immunotherapy has recently emerged as a treatment strategy which stimulates the human immune system to kill tumor cells. Tumor immunotherapy is based on immune editing, which enhances the antigenicity of tumor cells and increases the tumoricidal effect o
The suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the negative regulation of several cytokine pathways, particularly the receptor-associated tyrosine kinase/signal transducer and activator of transcription (Jak/STAT) pathways of transcriptional activation. SOCS-1 (also ...