Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts. These opposite processes allow the accommodation of bones to dynamic mechanical forces, altering bone mass in response to changin...
Orthodontic tooth movement (OTM) is a prime example of mechanically induced bone remodeling. However, the cell-specific role of the ion channels Piezo1 and Piezo2 in OTM has not been investigated yet. Here we first identify the expression of PIEZO1/2 in the dentoalveolar hard tissues. ...
Bone modeling, remodeling, and the mutual regulation of bone resorption and formation In vertebrates, bone modeling and remodeling are essential processes that are activated throughout life and are regulated by distinct temporal cellular constituents that ensure functional bone adaptation and vertebrate surv...
Regulation of Calcium Homeostasis in the Pancreatic Beta CellAbstract A complementary theoretical and experimental investigation is proposed to test two hypotheses regarding the mechanical adaptation of cortical bone: (1) changes in a bone's homeostatic mechanical state relate to the spatial pattern of...
Regulation of bone mass by mechanical loading: microarchitecture and genetics. Curr Osteoporos Rep 2005; 3 (2): 46-51.Suva LJ, Gaddy D, Perrien DS, Thomas RL, Findlay DM. Regulation of bone mass by mechanical loading: microarchitecture and genetics. Current osteoporosis reports 2005;3(2):46...
Bone remodelling: A signalling system for osteoclast regulation Two physiological regulators of osteoclast maturation have recently been identified: the secreted protein osteoprotegerin and the cell-surface ligand to wh... E Filvaroff,R Derynck - 《Current Biology Cb》 被引量: 111发表: 1998年 加载...
Metastasized cancer cells interact with cells such as the bone-resorbing osteoclasts to alter bone remodeling. Exercise, often suggested as an intervention for cancer patients, regulates bone remodeling via osteocytes. Osteocytes also signal to endothelial cells, which may affect cancer cell ...
Mechanical regulation of bone remodeling Bone Res, 10 (2022), p. 16 Google Scholar [11] W. Sun, Y. Li, J. Li, et al. Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl- channel Anoctamin 1 Commun Biol, 6 (2023), p. 407 View in ScopusGoogl...
Trabecular and cortical endosteal bone surfaces in the femoral head underwent significant bone resorption in microgravity, enlarging the marrow cavity. Cells isolated from the femoral head marrow compartment showed significant down-regulation of gene expression markers for early mesenchymal and hematopoietic ...
hip replacement,非骨水泥型人工髋关节假体固定界面骨整合力学分析 Three-dimensional finite element analysis on mechanical behavior of the bone remodeling and bone integration between the bone-implant interface after hip replacement,Three-dimensional,finite,element,analysis,on,mechanical,behavior,of,the,bone ...