The homeostatic role of the skeleton has expanded beyond the regulation of bone growth and remodeling to fulfill two novel endocrine functions: regulation of energy metabolism and male fertility. Bone regulates energy metabolism by favoring insulin secretion, insulin sensitivity, and energy expenditure. ...
their bone tissue can recover from trauma without scar formation. Bone fracture healing proceeds through four phases: hematoma, soft callus, hard callus, and hard callus remodeling.23Bone healing starts with inflammation resulting from high-energy trauma, and immediate activation of the coagulation casc...
long considered the only effector cells in vivo that participate in bone remodeling by resorbing bone matrix, have emerged as an important cell type in the process of bone erosion in RA. Osteoclasts are multinuclear giant cells that are differentiated from monocyte-macrophage lineage precursor cells ...
Before examining how bone is affected by microgravity, it is important to understand bone function in 1G. Under normal circumstances, bone remodeling is an adaptive and balanced process where bone resorption and formation are coupled to regulate homeostasis of bone tissue9. The overall process relies...
Emerging evidence now indicates that mitochondria are central regulators of neural stem cell (NSC) fate decisions and are crucial for both neurodevelopment and adult neurogenesis, which in turn contribute to cognitive processes in the mature brain. Inher
Bone remodeling involves tightly regulated bone-resorbing osteoclasts and bone-forming osteoblasts. Determining osteoclast function is central to understanding bone diseases such as osteoporosis and osteopetrosis. Here, we report a novel function of the F-actin binding and regulatory protein SWAP-70 in os...
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e....
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have numerous shared characteristics between mice and humans. Human counterparts of mouse DC progenitors have been identified by their shared transcriptional signatures and developmental potential. New findings continue to ...
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142, 943–953 (2010). Article CAS PubMed Google Scholar Guan, D. et al. Diet-induced circadian enhancer remodeling synchronizes opposing hepatic lipid metabolic processes. Cell 174, 831–...
Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue Osteocyte apoptosis is spatially and temporally linked to bone fatigue-induced microdamage and to subsequent intracortical remodeling. Specifically, osteoc... Luis,Cardoso,Brad,... - 《Journal of Bone & ...